ArticleGenome biology and evolution2012
The Oxytricha trifallax mitochondrial genome.
Article in Genome biology and evolution, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
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- Charting the landscape of organellar genome evolution in eustigmatophyte algae.bioRxiv : the preprint server for biology · 2026Article
- Insights into the mitochondrial genome structure and phylogenetic placement of Theileria velifera in comparison to other apicomplexan parasites.Scientific reports · 2025Article
- Novel findings on the mitochondria in ciliates, with description of mitochondrial genomes of six representatives.Marine life science & technology · 2025Article
- A cryptic plastid and a novel mitochondrial plasmid inOpen biology · 2024Article
- Mitogenomic architecture and evolution of the soil ciliatesmSystems · 2024Article
- The Ancestral Shape of the Access Proton Path of Mitochondrial ATP Synthases Revealed by a Split Subunit-a.Molecular biology and evolution · 2023Article
- Exploration of the Nuclear Proteomes in the CiliateMicroorganisms · 2023Article
- Characterization of the complete mitochondrial genome of Miamiensis avidus causing flatfish scuticociliatosis.Genetica · 2022Article
- The Codon Usage Bias Analysis of Free-Living Ciliates' Macronuclear Genomes and Clustered Regularly Interspaced Short Palindromic Repeats/Cas9 Vector Construction ofFrontiers in microbiology · 2022Article
- Mitochondrial Genomic Landscape: A Portrait of the Mitochondrial Genome 40 Years after the First Complete Sequence.Life (Basel, Switzerland) · 2021Article
- Characterization and Comparative Analyses of Mitochondrial Genomes in Single-Celled Eukaryotes to Shed Light on the Diversity and Evolution of Linear Molecular Architecture.International journal of molecular sciences · 2021Article
- Identification and phylogenetic analysis of RNA binding domain abundant in apicomplexans or RAP proteins.Microbial genomics · 2021Article
- Phage Origin of Mitochondrion-Localized Family A DNA Polymerases in Kinetoplastids and Diplonemids.Genome biology and evolution · 2021Article
- Genome Analysis of a Verrucomicrobial Endosymbiont With a Tiny Genome Discovered in an Antarctic Lake.Frontiers in microbiology · 2021Article
- Morphology, ultrastructure, genomics, and phylogeny of Euplotes vanleeuwenhoeki sp. nov. and its ultra-reduced endosymbiont "Candidatus Pinguicoccus supinus" sp. nov.Scientific reports · 2020Article
- Comparative Studies on the Polymorphism and Copy Number Variation of mtSSU rDNA in Ciliates (Protista, Ciliophora): Implications for Phylogenetic, Environmental, and Ecological Research.Microorganisms · 2020Article
- Convergent Evolution of Hydrogenosomes from Mitochondria by Gene Transfer and Loss.Molecular biology and evolution · 2020Article
- Programmed genome rearrangements in Oxytricha produce transcriptionally active extrachromosomal circular DNA.Nucleic acids research · 2019Article
- The complete mitochondrial genome ofMitochondrial DNA. Part B, Resources · 2019Article
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Authors and funding
11 authors.
Funding
Abstract
The Oxytricha trifallax mitochondrial genome contains the largest sequenced ciliate mitochondrial chromosome (~70 kb) plus a ~5-kb linear plasmid bearing mitochondrial telomeres. We identify two new ciliate split genes (rps3 and nad2) as well as four new mitochondrial genes (ribosomal small subunit protein genes: rps- 2, 7, 8, 10), previously undetected in ciliates due to their extreme divergence. The increased size of the Oxytricha mitochondrial genome relative to other ciliates is primarily a consequence of terminal expansions, rather than the retention of ancestral mitochondrial genes. Successive segmental duplications, visible in one of the two Oxytricha mitochondrial subterminal regions, appear to have contributed to the genome expansion. Consistent with pseudogene formation and decay, the subtermini possess shorter, more loosely packed open reading frames than the remainder of the genome. The mitochondrial plasmid shares a 251-bp region with 82% identity to the mitochondrial chromosome, suggesting that it most likely integrated into the chromosome at least once. This region on the chromosome is also close to the end of the most terminal member of a series of duplications, hinting at a possible association between the plasmid and the duplications. The presence of mitochondrial telomeres on the mitochondrial plasmid suggests that such plasmids may be a vehicle for lateral transfer of telomeric sequences between mitochondrial genomes. We conjecture that the extreme divergence observed in ciliate mitochondrial genomes may be due, in part, to repeated invasions by relatively error-prone DNA polymerase-bearing mobile elements.
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