Evidence map›Paper›PMID 22179186›Full record

ArticleMedical molecular morphology2011

Acquired cystic disease-associated renal cell carcinoma: an immunohistochemical and fluorescence in situ hybridization study.

Naoto Kuroda, Motoki Yamashita, Yoshiyuki Kakehi, Ondrej Hes, Michal Michal, Gang-Hong Lee

Abstract read
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In one paragraph

Article in Medical molecular morphology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.

  1. Guideline
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  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 3 countries.

Naoto KurodaDepartment of Diagnostic Pathology, Kochi Red Cross Hospital, Shin-honmachi, Kochi, Japan. kurochankochi@yahoo.co.jp
Motoki Yamashita
Yoshiyuki Kakehi
Ondrej Hes
Michal Michal
Gang-Hong Lee
Kagawa University · JPCharles University · CZJapanese Red Cross Kochi Hospital · JPKōchi University · JPUniversity Hospital Plzen · CZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acquired cystic disease (ACD)-associated renal cell carcinoma (RCC) has been recently identified. However, there are only a few genetic studies to date. In this article, we performed an immunohistochemical and fluorescence in situ hybridization (FISH) study for six cases including one case with sarcomatoid change. As a result, we observed frequent immunohistochemical expression of AMACR. FISH of chromosome 3 showed trisomy for three cases, monosomy for two cases, and disomy for one case. Additionally, FISH of chromosome 16 showed trisomy for three cases, monosomy for two cases, and both trisomy and monosomy for one case. Furthermore, both the carcinomatous area and the sarcomatoid area of one ACD-associated RCC with sarcomatoid change revealed monosomy of chromosomes 3, 9, and 16 but showed disomy of chromosome 14. In conclusion, the numerical abnormalities of chromosomes 3 and 16, irrespective of gain or loss, may be characteristic of ACD-associated RCC.

Indexed as

AdultAgedAneuploidyCarcinoma, Renal CellChromosomes, Human, Pair 14Chromosomes, Human, Pair 16Chromosomes, Human, Pair 3Chromosomes, Human, Pair 9HumansIn Situ Hybridization, FluorescenceKeratin-7Kidney Diseases, CysticKidney NeoplasmsMaleMiddle AgedMitochondriaalpha-methylacyl-CoA racemaseKeratin-7PAX2 protein, humanPAX2 Transcription FactorRacemases and Epimerases

Identifiers

PMID22179186
OpenAlexW2051295839

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.