ArticleClinics (Sao Paulo, Brazil)2011
Prenatal tobacco exposure is related to neurobehavioral modifications in infants of adolescent mothers.
Article in Clinics (Sao Paulo, Brazil), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 17 citations in OpenAlex.
- Vaping and Smoking in Pregnancy-A Meta-Analysis of Neurobehavioural Development in Prenatally Exposed Offspring.Acta paediatrica (Oslo, Norway : 1992) · 2025Pooled it
- Infant neurobehavioural consequences of prenatal cigarette exposure: A systematic review and meta-analysis.Acta paediatrica (Oslo, Norway : 1992) · 2020Pooled it
- Impact of Maternal Smoking During Pregnancy on Fetal and Neonatal Neurobehavioral Development: A Narrative Review.Rhode Island medical journal (2013) · 2026Review
- Parental factors predicting social deviance and psychological outcomes in offspring: Evidence from the Avon Longitudinal Study of Parents and Children (ALSPAC).Nordisk alkohol- & narkotikatidskrift : NAT · 2024Article
- Prenatal and Early Postnatal Exposure to Cigarette Smoke Decreases BDNF/TrkB Signaling and Increases Abnormal Behaviors Later in Life.The international journal of neuropsychopharmacology · 2016Article
- Altered placental DNA methylation patterns associated with maternal smoking: current perspectives.Advances in genomics and genetics · 2015Article
- Assessment and evaluation of the high risk neonate: the NICU Network Neurobehavioral Scale.Journal of visualized experiments : JoVE · 2014Article
- Associations of prenatal tobacco and insecticide co-exposures with neurobehavioral responses among children born to pregnant women exposed to cannabis.Neurotoxicology and teratologyArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPrenatal tobacco exposure interferes with neonatal outcomes.
objectiveTo determine the neonatal neurobehavioral effects of in utero tobacco exposure.
methodsThis prospective cross-sectional study included healthy, term, with birth weight appropriate for gestacional age neonates without exposure to alcohol, drugs, or infections, born to adolescent mothers without psychiatric disorders or post-traumatic stress. Infants were classified according to in utero tobacco exposure, as identified by the Composite International Diagnostic Interview administered to mothers. Neurobehavior was assessed by the Neonatal Intensive Care Unit Network Neurobehavioral Scale. Both tools were administered between 24 and 72 hours after birth. Neurobehavioral outcomes were compared between exposed and nonexposed infants by ANOVA. The associations between neurobehavioral scores and number of cigarettes smoked were studied by linear correlation.
resultsDuring the study, 928 newborns of adolescent mothers were born, and 388 were included in the study. Of these, 23 were exposed to tobacco, and 365 neonates were not exposed. There were no differences between the groups in gestational age, birth weight, post-natal age at the exam, or time between last feeding and exam. Exposed neonates showed higher scores on arousal (p = 0.004), excitability (p = 0.003), and stress/abstinence signals (p = 0.019) and a lower score on regulation (p = 0.025). After adjusting for the type of anesthesia, mode of delivery, gender, age at neurologic exam, exam duration and time between last feeding and exam, differences in arousal and excitability remained significant. The mean number of cigarettes consumed daily was positively correlated with lethargy (p = 0.013) and inversely with attention (p = 0.043).
conclusionsNeonates exposed in utero to tobacco showed worse neurobehavioral performance between 24 and 48 hours of life.
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