Evidence map›Paper›PMID 22179123›Full record

ReviewThe Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry2013

Molecular control of axon branching.

Parizad M Bilimoria, Azad Bonni

Abstract readReview
In one paragraph

Review in The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Article
  2. Article
  3. AQP5 Regulates Corneal Nerve Distribution Through NETRIN-1 and SLIT3.Investigative ophthalmology & visual science · 2025
    Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Mathematical models of neuronal growth.Biomechanics and modeling in mechanobiology · 2022
    Review
  9. SNARE-Mediated Exocytosis in Neuronal Development.Frontiers in molecular neuroscience · 2020
    Review
  10. Article
  11. Review
  12. Neuronal GAP-Porf-2 transduces EphB1 signaling to brake axon growth.Cellular and molecular life sciences : CMLS · 2018
    Article
  13. Article
  14. Review
  15. Article
  16. MAP7 Regulates Axon Collateral Branch Development in Dorsal Root Ganglion Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017
    Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Parizad M BilimoriaDepartment of Neurobiology and Program in Neuroscience, Harvard Medical School, Boston, MA, USA.
Azad Bonni

Funding

SIGNAL TRANSDUCTION PATHWAYS REGULATING NEURON SURVIVALR01NS041021 · NINDS · WASHINGTON UNIVERSITY · PI GABEL, HARRISON W · 2001 to 2023
$7.7M
Cell Cycle Regulation of Neuronal ApoptosisR01NS047188 · NINDS · HARVARD MEDICAL SCHOOL · PI BONNI, AZAD · 2007 to 2010
$1.3M
NINDS NIH HHS NS041021NINDS NIH HHS NS047188NINDS NIH HHS R01 NS041021NINDS NIH HHS R01 NS047188
6 · The paper itself

Abstract

Axon branching is a complex morphological process, the regulation of which we are just beginning to understand. Many factors known to be important for axon growth and guidance have emerged as key regulators of axon branching. The extrinsic factors implicated in axon branching include traditional axon guidance cues such as the slits, semaphorins, and ephrins; neurotrophins such as BDNF; the secreted glycoprotein Wnt; the extracellular matrix protein anosmin-1; and certain transmembrane cell adhesion molecules--as well as sensory experience and neuronal activity. Although less is known about the intracellular control of axon branching, in recent years significant advances have been made in this area. Kinases and their regulators, Rho GTPases and their regulators, transcription factors, ubiquitin ligases, and several microtubule and actin-binding proteins are now implicated in the control of axon branching. It is likely that many more branching regulators remain to be discovered, as do the links between extrinsic cues and intracellular signaling proteins in the control of axon branching.

Indexed as

AnimalsAxonsCytoskeletal ProteinsExtracellular Matrix ProteinsNeuronsPhosphotransferasesrho GTP-Binding ProteinsTranscription FactorsUbiquitin-Protein LigasesCytoskeletal ProteinsExtracellular Matrix ProteinsPhosphotransferasesrho GTP-Binding ProteinsTranscription FactorsUbiquitin-Protein Ligases

Identifiers

PMID22179123
PMCPMC3490022

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.