ArticleNature neuroscience2011
Visual map development depends on the temporal pattern of binocular activity in mice.
Article in Nature neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
85 citing papers in PubMed.
- Auditory stimuli mimicking ambient sounds drive temporal "delta-brushes" in premature infants.PloS one · 2013Trial
- Retinal waves shape starburst amacrine cell dendrite development through a direction-selective dendritic computation.Cell reports · 2026Article
- A toolbox for navigating and analyzing the spatiotemporal properties of retinal waves.bioRxiv : the preprint server for biology · 2025Article
- High-density Multielectrode Array Recordings of Retinal Waves Using An Electrophysiology Platform.Journal of visualized experiments : JoVE · 2025Article
- Activity-dependent synaptic competition and dendrite pruning in developing mitral cells.Frontiers in neural circuits · 2025Review
- Activity-Dependent Synapse Refinement: From Mechanisms to Molecules.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2024Review
- Hebbian instruction of axonal connectivity by endogenous correlated spontaneous activity.Science (New York, N.Y.) · 2024Article
- Mapping the Retina onto the Brain.Cold Spring Harbor perspectives in biology · 2024Review
- Shaping the olfactory map: cell type-specific activity patterns guide circuit formation.Frontiers in neural circuits · 2024Review
- Heterosynaptic plasticity-induced modulation of synapses.The journal of physiological sciences : JPS · 2023Review
- Differentiation and functional connectivity of fetal tectal transplants.Neural regeneration research · 2023Article
- BDNF signaling in correlation-dependent structural plasticity in the developing visual system.PLoS biology · 2023Article
- Mesoscale calcium imagingFrontiers in neuroscience · 2023Review
- Network instability dynamics drive a transient bursting period in the developing hippocampus in vivo.eLife · 2022Article
- Nicotine-mediated activation of α2 nAChR-expressing OLM cells in developing mouse brains disrupts OLM cell-mediated control of LTP in adolescence.Neurobiology of learning and memory · 2022Article
- Epigenetic and Transcriptional Regulation of Spontaneous and Sensory Activity Dependent Programs During Neuronal Circuit Development.Frontiers in neural circuits · 2022Review
- Molecular mechanisms of synaptogenesis.Frontiers in synaptic neuroscience · 2022Review
- Live imaging of retinotectal mapping reveals topographic map dynamics and a previously undescribed role for Contactin 2 in map sharpening.Development (Cambridge, England) · 2021Article
- Mechanisms governing activity-dependent synaptic pruning in the developing mammalian CNS.Nature reviews. Neuroscience · 2021Review
- Article
25 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
4 authors.
Funding
Abstract
Binocular competition is thought to drive eye-specific segregation in the developing visual system, potentially through Hebbian synaptic learning rules that are sensitive to correlations in afferent activity. Altering retinal activity can disrupt eye-specific segregation, but little is known about the temporal features of binocular activity that modulate visual map development. We used optogenetic techniques to directly manipulate retinal activity in vivo and identified a critical period before eye opening in mice when specific binocular features of retinal activity drive visual map development. Synchronous activation of both eyes disrupted segregation, whereas asynchronous stimulation enhanced segregation. The optogenetic stimulus applied was spatially homogenous; accordingly, retinotopy of ipsilateral projections was markedly perturbed, but contralateral retinotopy was unaffected or even improved. These results provide direct evidence that the synchrony and precise temporal pattern of binocular retinal activity during a critical period in development regulates eye-specific segregation and retinotopy in the developing visual system.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.