ArticleJournal of developmental and behavioral pediatrics : JDBP2012
Language impairment in children perinatally infected with HIV compared to children who were HIV-exposed and uninfected.
Article in Journal of developmental and behavioral pediatrics : JDBP, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01418014 (Adolescent Master Protocol), which is not on this map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Adolescent Master Protocol
Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Cross-cultural assessment of HIV-associated cognitive impairment using the Kaufman assessment battery for children: a systematic review.Journal of the International AIDS Society · 2017Pooled it
- HIV-Associated Cognitive Impairment in Perinatally Infected Children: A Meta-analysis.Pediatrics · 2016Pooled it
- Trajectory Analysis of Cognitive Outcomes in Children With Perinatal HIV.The Pediatric infectious disease journal · 2019Trial
- Comparison of developmental milestone attainment in early treated HIV-infected infants versus HIV-unexposed infants: a prospective cohort study.BMC pediatrics · 2017Trial
- Correlates of age at attainment of developmental milestones in HIV-infected infants receiving early antiretroviral therapy.The Pediatric infectious disease journal · 2015Trial
- Evidence of functional connectivity disruptions between auditory and non-auditory regions in adolescents living with HIV.Frontiers in systems neuroscience · 2025Article
- Reduced white matter maturation in the central auditory system of children living with HIV.Frontiers in neuroimaging · 2024Article
- Article
- Neurocognitive outcomes of children exposed to and living with HIV aged 3-5 years in Kilifi, Kenya.Frontiers in reproductive health · 2023Article
- Ageing with HIV: a longitudinal study of markers of resilience in young adults with perinatal exposure to HIV, with or without perinatally acquired HIV.Journal of the International AIDS Society · 2022Article
- In utero and peripartum antiretroviral exposure as predictor of cognition in 6- to 10-year-old HIV-exposed Ugandan children - a prospective cohort study.HIV medicine · 2021Article
- Congenital Cytomegalovirus and Human Immunodeficiency Virus: Effects on Hearing, Speech and Language Development, and Clinical Outcomes in Children.Frontiers in pediatrics · 2021Review
- Child functioning and disability in children living with human immunodeficiency virus in a semi-rural healthcare setting in South Africa.African journal of primary health care & family medicine · 2020Article
- Article
- Risk for Speech and Language Impairments in Preschool Age HIV-exposed Uninfected Children With In Utero Combination Antiretroviral Exposure.The Pediatric infectious disease journal · 2018Article
- Longitudinal Evaluation of Language Impairment in Youth With Perinatally Acquired Human Immunodeficiency Virus (HIV) and Youth With Perinatal HIV Exposure.Journal of the Pediatric Infectious Diseases Society · 2016Article
- Article
- Learning and Memory in Children and Adolescents With Perinatal HIV Infection and Perinatal HIV Exposure.The Pediatric infectious disease journal · 2016Article
- Atazanavir exposure in utero and neurodevelopment in infants: a comparative safety study.AIDS (London, England) · 2016Article
- The PHACS SMARTT Study: Assessment of the Safety of In Utero Exposure to Antiretroviral Drugs.Frontiers in immunology · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 8 institutions in 1 country.
Funding
Abstract
objectiveTo investigate the risk for language impairment (LI) in children perinatally infected or exposed to HIV.
methodsWe evaluated the prevalence of LI in 7- to 16-year-old children with perinatal HIV infection (HIV+) compared with HIV-exposed and uninfected children, using a comprehensive standardized language test (Clinical Evaluation of Language Functioning-Fourth Edition [CELF-4]). LI was classified as primary LI (Pri-LI) (monolingual English exposure and no cognitive or hearing impairment), concurrent LI (Con-LI) (cognitive or hearing impairment), or no LI. Associations of demographic, caregiver, HIV disease, and antiretroviral treatment factors with LI category were evaluated using univariate and multivariable logistic regression models.
resultsOf the 468 children with language assessments, 184 (39%) had LI. No difference was observed by HIV infection status for overall LI or for Pri-LI or Con-LI; mean (SD) CELF-4 scores were 88.5 (18.4) for HIV+ versus 87.5 (17.9) for HIV-exposed and uninfected children. After adjustment, black children had higher odds of Pri-LI versus no LI (adjusted odds ratio [aOR] = 2.43, p = .03). Children who were black, Hispanic, had a caregiver with low education or low intelligence quotient, or a nonbiological parent as caregiver had higher odds of Con-LI versus no LI. Among HIV+ children, viral load >400 copies/mL (aOR = 3.04, p < .001), Centers for Disease Control and Prevention Class C (aOR = 2.19, p = .02), and antiretroviral treatment initiation <6 months of age (aOR = 2.12, p = .02) were associated with higher odds of Con-LI versus no LI.
conclusionsChildren perinatally exposed to HIV are at high risk for LI, but such risk was not increased for youth with HIV. Risk factors differed for Pri-LI and Con-LI.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.