ArticleNature2011
A sensing array of radically coupled genetic 'biopixels'.
Article in Nature, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 135 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
135 citing papers in PubMed.
- Engineered E. coli swarming for binary and analog input recording.Molecular systems biology · 2026Article
- PEG-Based Living Hydrogels Engineered for Tunable Production of Bioactive Lipopeptides.ACS applied polymer materials · 2026Article
- Living Hydrogels: Harnessing Microorganism-Material Synergy for Next-Generation Therapeutics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- An immunostimulant nanomedicine enhances radioimmunotherapy by remodeling the tumor immunosuppressive landscape after radiotherapy.Acta pharmaceutica Sinica. B · 2026Article
- Intracellularly coupled oscillators for synthetic biology.Nature communications · 2025Review
- Genetic "expiry-date" circuits control lifespan of synthetic scavenger bacteria for safe bioremediation.Nucleic acids research · 2025Article
- Thermodynamically consistent, reduced models of gene regulatory networks.Royal Society open science · 2025Article
- Partitioning of a 2-bit hash function across 66 communicating cells.Nature chemical biology · 2025Article
- Non-Hermitian Global Synchronization.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Article
- Emergence of synchronized growth oscillations in filamentous fungi.Journal of the Royal Society, Interface · 2024Article
- From resonance to chaos by modulating spatiotemporal patterns through a synthetic optogenetic oscillator.Nature communications · 2024Article
- Engineered bacterial therapeutics for detecting and treating CRC.Trends in cancer · 2024Review
- Synthetic Homoserine Lactone Sensors for Gram-PositiveACS synthetic biology · 2024Article
- Accelerating Genetic Sensor Development, Scale-up, and Deployment Using Synthetic Biology.Biodesign research · 2024Article
- Quantitative microbiology with widefield microscopy: navigating optical artefacts for accurate interpretations.Npj imaging · 2024Article
- Competition and evolutionary selection among core regulatory motifs in gene expression control.Nature communications · 2023Article
- Applications of synthetic biology in medical and pharmaceutical fields.Signal transduction and targeted therapy · 2023Review
- Genetic Programming by Nitric Oxide-Sensing Gene Switch System in Tumor-Targeting Bacteria.Biosensors · 2023Article
- Synthetic Micrographs of Bacteria (SyMBac) allows accurate segmentation of bacterial cells using deep neural networks.BMC biology · 2022Article
75 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors.
Funding
Abstract
Although there has been considerable progress in the development of engineering principles for synthetic biology, a substantial challenge is the construction of robust circuits in a noisy cellular environment. Such an environment leads to considerable intercellular variability in circuit behaviour, which can hinder functionality at the colony level. Here we engineer the synchronization of thousands of oscillating colony 'biopixels' over centimetre-length scales through the use of synergistic intercellular coupling involving quorum sensing within a colony and gas-phase redox signalling between colonies. We use this platform to construct a liquid crystal display (LCD)-like macroscopic clock that can be used to sense arsenic via modulation of the oscillatory period. Given the repertoire of sensing capabilities of bacteria such as Escherichia coli, the ability to coordinate their behaviour over large length scales sets the stage for the construction of low cost genetic biosensors that are capable of detecting heavy metals and pathogens in the field.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.