ArticleNeuroImage2012
Imaging acute ischemic tissue acidosis with pH-sensitive endogenous amide proton transfer (APT) MRI--correction of tissue relaxation and concomitant RF irradiation effects toward mapping quantitative cerebral tissue pH.
Article in NeuroImage, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.
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Who cites it
75 citing papers in PubMed, 114 citations in OpenAlex.
- Article
- A rapid and accurate guanidine CEST imaging in ischemic stroke using a machine learning approach.Physics in medicine and biology · 2026Article
- The Role of Tumor pH in Breast Cancer Imaging: Biology, Diagnostic Applications, and Emerging Techniques.Diagnostics (Basel, Switzerland) · 2025Review
- Amide proton transfer MRI may reflect effective reperfusion and predict functional outcomes in patients with ischemic stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2025Article
- Physics-guided multi-dimensional scan optimization and quasi-steady-state reconstruction to enhance CEST MRI sensitivity efficiency and quantification accuracy.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2025Article
- Improving standardization and accuracy of in vivo omega plot exchange parameter determination using rotating-frame model-based fitting of quasi-steady-state Z-spectra.Magnetic resonance in medicine · 2025Article
- Quasi-steady-state (QUASS) reconstruction enhances TMagnetic resonance in medicine · 2024Article
- Comparison of model-free Lorentzian and spinlock model-based fittings in quantitative CEST imaging of acute stroke.Magnetic resonance in medicine · 2023Article
- Detection of tissue pH with quantitative chemical exchange saturation transfer magnetic resonance imaging.NMR in biomedicine · 2023Review
- Demonstration of accurate multi-pool chemical exchange saturation transfer MRI quantification - Quasi-steady-state reconstruction empowered quantitative CEST analysis.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2023Article
- In vivo pH mapping with omega plot-based quantitative chemical exchange saturation transfer MRI.Magnetic resonance in medicine · 2023Article
- Quasi-steady-state amide proton transfer (QUASS APT) MRI enhances pH-weighted imaging of acute stroke.Magnetic resonance in medicine · 2022Article
- Application of a Markov chain Monte Carlo method for robust quantification in chemical exchange saturation transfer magnetic resonance imaging.Quantitative imaging in medicine and surgery · 2022Article
- Brain-targeting, acid-responsive antioxidant nanoparticles for stroke treatment and drug delivery.Bioactive materials · 2022Article
- Refined Ischemic Penumbra Imaging with Tissue pH and Diffusion Kurtosis Magnetic Resonance Imaging.Translational stroke research · 2021Review
- Quasi-steady-state chemical exchange saturation transfer (QUASS CEST) MRI analysis enables TJournal of magnetic resonance (San Diego, Calif. : 1997) · 2021Article
- Alkaline brain pH shift in rodent lithium-pilocarpine model of epilepsy with chronic seizures.Brain research · 2021Article
- Analysis Protocol for the Quantification of Renal pH Using Chemical Exchange Saturation Transfer (CEST) MRI.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Renal pH Imaging Using Chemical Exchange Saturation Transfer (CEST) MRI: Basic Concept.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Article
15 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Amide proton transfer (APT) MRI is sensitive to ischemic tissue acidosis and has been increasingly used as a research tool to investigate disrupted tissue metabolism during acute stroke. However, magnetization transfer asymmetry (MTR(asym)) analysis is often used for calculating APT contrast, which only provides pH-weighted images. In addition to pH-dependent APT contrast, in vivo MTR(asym) is subject to a baseline shift (ΔMTR'(asym)) attributable to the slightly asymmetric magnetization transfer (MT) effect. Additionally, APT contrast approximately scales with T(1) relaxation time. Tissue relaxation time may also affect the experimentally obtainable APT contrast via saturation efficiency and RF spillover effects. In this study, we acquired perfusion, diffusion, relaxation and pH-weighted APT MRI data, and spectroscopy (MRS) in an animal model of acute ischemic stroke. We modeled in vivo MTR(asym) as a superposition of pH-dependent APT contrast and a baseline shift ΔMTR'(asym) (i.e., MTR(asym)=APTR(pH)+ΔMTR'(asym)), and quantified tissue pH. We found pH of the contralateral normal tissue to be 7.03±0.05 and the ipsilateral ischemic tissue pH was 6.44±0.24, which correlated with tissue perfusion and diffusion rates. In summary, our study established an endogenous and quantitative pH imaging technique for improved characterization of ischemic tissue acidification and metabolism disruption.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.