Evidence map›Paper›PMID 22178808›Full record

SynthesisNeuroImage2012

Modelling neural correlates of working memory: a coordinate-based meta-analysis.

C Rottschy, R Langner, I Dogan, K Reetz, A R Laird, J B Schulz, P T Fox, S B Eickhoff

Registry-linked trialAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in NeuroImage, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04545294 (Online Left-hemispheric Frontoparietal Theta In-phase tACS During Working Memory Training in Schizophrenia Patients), which is not on this map. Cited by 485 papers, 17 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
485citing papers in PubMed, 17 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04545294 nacompletednot on this mapstarted 2019, after this paper: background citation

Online Left-hemispheric Frontoparietal Theta In-phase tACS During Working Memory Training in Schizophrenia Patients: A Pilot Randomized Double-blind, Sham-controlled Study of the Effects on Negative Symptoms

TypeinterventionalSponsorTri-Service General Hospital (TSGH)Ran2019 to 2020Enrolled36ConditionsSchizophrenia, Schizoaffective Disorder, Negative Symptoms, Working Memory TrainingArmsTheta tACS
3 · Its place in the literature

Who cites it

485 citing papers in PubMed, 17 syntheses or guidelines pooled it.

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  15. A Cortical Surface-Based Meta-Analysis of Human Reasoning.Cerebral cortex (New York, N.Y. : 1991) · 2021
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425 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

C RottschyDepartment of Neurology, RWTH Aachen University, Aachen, Germany.
R Langner
I Dogan
K Reetz
A R Laird
J B Schulz
P T Fox
S B Eickhoff

Funding

Meta-anaylsis in human brain mappingR01MH074457 · NIMH · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI FOX, PETER THORNTON · 2006 to 2024
$10.5M
NIMH NIH HHS R01 MH074457NIMH NIH HHS R01-MH074457-01A1
6 · The paper itself

Abstract

Working memory subsumes the capability to memorize, retrieve and utilize information for a limited period of time which is essential to many human behaviours. Moreover, impairments of working memory functions may be found in nearly all neurological and psychiatric diseases. To examine what brain regions are commonly and differently active during various working memory tasks, we performed a coordinate-based meta-analysis over 189 fMRI experiments on healthy subjects. The main effect yielded a widespread bilateral fronto-parietal network. Further meta-analyses revealed that several regions were sensitive to specific task components, e.g. Broca's region was selectively active during verbal tasks or ventral and dorsal premotor cortex were preferentially involved in memory for object identity and location, respectively. Moreover, the lateral prefrontal cortex showed a division in a rostral and a caudal part based on differential involvement in task set and load effects. Nevertheless, a consistent but more restricted "core" network emerged from conjunctions across analyses of specific task designs and contrasts. This "core" network appears to comprise the quintessence of regions, which are necessary during working memory tasks. It may be argued that the core regions form a distributed executive network with potentially generalized functions for focussing on competing representations in the brain. The present study demonstrates that meta-analyses are a powerful tool to integrate the data of functional imaging studies on a (broader) psychological construct, probing the consistency across various paradigms as well as the differential effects of different experimental implementations.

Indexed as

Magnetic Resonance ImagingBrainHumansMemory, Short-TermNerve Net

Identifiers

PMID22178808
PMCPMC3288533

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.