ReviewCritical reviews in oncology/hematology2012
Mechanobiology of tumor invasion: engineering meets oncology.
Review in Critical reviews in oncology/hematology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed.
- Junctions at the crossroads: the impact of mechanical cues on endothelial cell-cell junction conformations and vascular permeability.American journal of physiology. Cell physiology · 2024Review
- Data Science Opportunities To Improve Radiotherapy Planning and Clinical Decision Making.Seminars in radiation oncology · 2024Review
- Engineering Heterogeneous Tumor Models for Biomedical Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Research of restricted migration evaluation of MDA-MB-231 cells in 2D and 3D co-culture models.Experimental biology and medicine (Maywood, N.J.) · 2023Article
- In Vitro Models of Ovarian Cancer: Bridging the Gap between Pathophysiology and Mechanistic Models.Biomolecules · 2023Review
- Human T cells loaded with superparamagnetic iron oxide nanoparticles retain antigen-specific TCR functionality.Frontiers in immunology · 2023Article
- Interplay between substrate rigidity and tissue fluidity regulates cell monolayer spreading.Soft matter · 2022Article
- A primer to traction force microscopy.The Journal of biological chemistry · 2022Review
- Fabricating Silicon Resonators for Analysing Biological Samples.Micromachines · 2021Review
- Extracellular matrix density regulates the formation of tumour spheroids through cell migration.PLoS computational biology · 2021Article
- Tutorial on laser speckle rheology: technology, applications, and opportunities.Journal of biomedical optics · 2020Review
- GPER Activation Inhibits Cancer Cell Mechanotransduction and Basement Membrane Invasion via RhoA.Cancers · 2020Article
- Predictive Factors of Positive Circumferential and Longitudinal Margins in Early T3 Colorectal Cancer Resection.International journal of surgical oncology · 2020Article
- Spatial Regulation of Mitochondrial Heterogeneity by Stromal Confinement in Micropatterned Tumor Models.Scientific reports · 2019Article
- Clinical doses of radiation reduce collagen matrix stiffness.APL bioengineering · 2018Article
- Nonlinear studies of tumor morphological stability using a two-fluid flow model.Journal of mathematical biology · 2018Article
- Development of a Novel 3D Tumor-tissue Invasion Model for High-throughput, High-content Phenotypic Drug Screening.Scientific reports · 2018Article
- TGF-β Sustains Tumor Progression through Biochemical and Mechanical Signal Transduction.Cancers · 2018Review
- In Vitro Modeling of Mechanics in Cancer Metastasis.ACS biomaterials science & engineering · 2018Review
- Regulation of ATP utilization during metastatic cell migration by collagen architecture.Molecular biology of the cell · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
The physical sciences and engineering have introduced novel perspectives into the study of cancer through model systems, tools, and metrics that enable integration of basic science observations with clinical data. These methods have contributed to the identification of several overarching mechanisms that drive processes during cancer progression including tumor growth, angiogenesis, and metastasis. During tumor cell invasion - the first clinically observable step of metastasis - cells demonstrate diverse and evolving physical phenotypes that cannot typically be defined by any single molecular mechanism, and mechanobiology has been used to study the physical cell behaviors that comprise the "invasive phenotype". In this review, we discuss the continually evolving pathological characterization and in vitro mechanobiological characterization of tumor invasion, with emphasis on emerging physical biology and mechanobiology strategies that have contributed to a more robust mechanistic understanding of tumor cell invasion. These physical approaches may ultimately help to better predict and identify tumor metastasis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.