ArticleDevelopmental biology2012
Regulation of a duplicated locus: Drosophila sloppy paired is replete with functionally overlapping enhancers.
Article in Developmental biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Asymmetric chromatin accessibility underlies anterior-posterior axis specification in moth fly embryos.PLoS biology · 2026Article
- Breaking anterior-posterior symmetry in the moth flybioRxiv : the preprint server for biology · 2025Article
- Anterior-posterior patterning of segments in Anopheles stephensi offers insights into the transition from sequential to simultaneous segmentation in holometabolous insects.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2023Article
- A Notch-dependent transcriptional mechanism controls expression of temporal patterning factors ineLife · 2022Article
- Enhancer redundancy in development and disease.Nature reviews. Genetics · 2021Review
- Transcriptional Enhancers inGenetics · 2020Review
- Article
- Redundant and Cryptic Enhancer Activities of theGenetics · 2019Article
- Studying Transcriptional Enhancers: The Founder Fallacy, Validation Creep, and Other Biases.Trends in genetics : TIG · 2019Review
- A damped oscillator imposes temporal order on posterior gap gene expression in Drosophila.PLoS biology · 2018Article
- Different modes of enhancer-specific regulation by Runt and Even-skipped duringMolecular biology of the cell · 2017Article
- Odd-paired controls frequency doubling ineLife · 2016Article
- Krüppel Expression Levels Are Maintained through Compensatory Evolution of Shadow Enhancers.Cell reports · 2015Article
- Genome-wide identification and characterization of Fox genes in the silkworm, Bombyx mori.Functional & integrative genomics · 2015Review
- Co-regulation of invected and engrailed by a complex array of regulatory sequences in Drosophila.Developmental biology · 2014Article
- In silico evolution of the hunchback gene indicates redundancy in cis-regulatory organization and spatial gene expression.Journal of bioinformatics and computational biology · 2014Article
- Article
- Engrailed cooperates directly with Extradenticle and Homothorax on a distinct class of homeodomain binding sites to repress sloppy paired.Developmental biology · 2012Article
- The cis-regulatory dynamics of the Drosophila CNS determinant castor are controlled by multiple sub-pattern enhancers.Gene expression patterns : GEPArticle
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2 authors.
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Abstract
In order to investigate regulation and redundancy within the sloppy paired (slp) locus, we analyzed 30 kilobases of DNA encompassing the tandem, coordinately regulated slp1 and slp2 transcription units. We found a remarkable array of stripe enhancers with overlapping activities surrounding the slp1 transcription unit, and, unexpectedly, glial cell enhancers surrounding slp2. The slp stripe regulatory region generates 7 stripes at blastoderm, and later 14 stripes that persist throughout embryogenesis. Phylogenetic analysis among drosophilids suggests that the multiplicity of stripe enhancers did not evolve through recent duplication. Most of the direct integration among cis-regulatory modules appears to be simply additive, with one notable exception. Despite the apparent redundancy among stripe enhancers, transgenic rescue suggests that most are required for full function, to maintain wingless expression and parasegment boundaries throughout embryogenesis. Transgenic rescue also reveals indirect positive autoregulation by the 7 early stripes, without which alternate stripes within the 14-stripe pattern are lost, leading to embryos with a pair-rule phenotype.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.