ReviewHormones and behavior2012
Salubrious effects of oxytocin on social stress-induced deficits.
Review in Hormones and behavior, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 91 citations in OpenAlex.
- Oxytocin modulates behavioral and physiological responses to a stressor in marmoset monkeys.Psychoneuroendocrinology · 2016Trial
- Pairing Mouse Social and Aversive Stimuli across Sexes Does Not Produce Social Aversion in Females.eNeuro · 2025Article
- Stress-reducing effect of laughter in live comedy performance from salivary α-amylase and salivary oxytocin.BMC research notes · 2025Article
- Promoting Child Wellness: A Narrative Review of Positive Childhood Experiences.Behavioral sciences (Basel, Switzerland) · 2025Review
- Oxytocin Intervention Mitigates Pathological and Behavioral Impairments in APP/PS1 Mice Subjected to Early Social Isolation.CNS neuroscience & therapeutics · 2025Article
- Male and female mice may respectively form stronger social aversive memories with same and different sex conspecifics.bioRxiv : the preprint server for biology · 2025Article
- Endogenous Oxytocin and Depressive Symptoms in Drug Abstainers: The Roles of Perceived Social Support and Drug Abstinence Self-Efficacy.Psychology research and behavior management · 2025Article
- Investigating the psychophysiological effects of NaiKan Therapy: salivary oxytocin and cortisol release.Frontiers in integrative neuroscience · 2025Article
- Effects of chronic empathic stress on synaptic efficacy, as well as short-term and long-term plasticity at the Schaffer collateral/commissural- CA1 synapses in the dorsal hippocampus of rats.Metabolic brain disease · 2024Article
- Social status predicts physiological and behavioral responses to chronic stress in rhesus monkeys.iScience · 2024Article
- The association between neuropeptide oxytocin and neuropsychiatric disorders after orthopedic surgery stress in older patients.BMC geriatrics · 2023Article
- Neural mechanisms of comforting: Prosocial touch and stress buffering.Hormones and behavior · 2023Review
- Effects of Different-Syllable Aggressive Calls on Food Intake and Gene Expression inAnimals : an open access journal from MDPI · 2023Article
- Oxytocin and oxygen: the evolution of a solution to the 'stress of life'.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- Why the cognitive "fountain of youth" may be upstream: Pathways to dementia risk and resilience through social connectedness.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022Article
- Effects of Chronic and Acute Intranasal Oxytocin Treatments on Temporary Social Separation in Adult Titi Monkeys (Frontiers in behavioral neuroscience · 2022Article
- Behavioral, neurochemical, and neuroimmune changes associated with social buffering and stress contagion.Neurobiology of stress · 2022Article
- Population variation alters aggression-associated oxytocin and vasopressin expressions in brains of Brandt's voles in field conditions.Frontiers in zoology · 2021Article
- Density-induced social stress alters oxytocin and vasopressin activities in the brain of a small rodent species.Integrative zoology · 2021Article
- Social enrichment attenuates chemotherapy induced pro-inflammatory cytokine production and affective behavior via oxytocin signaling.Brain, behavior, and immunity · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Social relationships are a fundamental aspect of life, affecting social, psychological, physiological, and behavioral functions. While positive social interactions can attenuate stress and promote health, the social environment can also be a major source of stress when it includes social disruption, confrontation, isolation, or neglect. Social stress can impair the basal function and stress-induced activation of the hypothalamic-pituitary-adrenal (HPA) axis, impairing function of multiple biological systems and posing a risk to mental and physical health. In contrast, social support can ameliorate stress-induced physiological and immunological deficits, reducing the risk of subsequent psychological distress and improving an individual's overall well-being. For better clinical treatment of these physiological and mental pathologies, it is necessary to understand the regulatory mechanisms of stress-induced pathologies as well as determine the underlying biological mechanisms that regulate social buffering of the stress system. A number of ethologically relevant animal models of social stress and species that form strong adult social bonds have been utilized to study the etiology, treatment, and prevention of stress-related disorders. While undoubtedly a number of biological pathways contribute to the social buffering of the stress response, the convergence of evidence denotes the regulatory effects of oxytocin in facilitating social bond-promoting behaviors and their effect on the stress response. Thus, oxytocin may be perceived as a common regulatory element of the social environment, stress response, and stress-induced risks on mental and physical health. This article is part of a Special Issue entitled Oxytocin, Vasopressin, and Social Behavior.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.