Evidence map›Paper›PMID 22178008›Full record

ArticleAppetite2012

Amygdala response to sucrose consumption is inversely related to artificial sweetener use.

K J Rudenga, D M Small

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Appetite, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  20. The Macronutrients, Appetite, and Energy Intake.Annual review of nutrition · 2016
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

K J RudengaInterdepartmental Neuroscience Program, Yale University, SHM L-200, New Haven, CT 06520, USA.
D M Small

Funding

Cognitive and affective influences on taste processingR01DC006706 · NIDCD · YALE UNIVERSITY · PI SMALL, DANA M · 2006 to 2018
$5.3M
The role of the amygdala in weight gain susceptibilityR01DK085579 · NIDDK · JOHN B. PIERCE LABORATORY, INC. · PI DE ARAUJO, IVAN E, SMALL, DANA M · 2010 to 2014
$3.6M
Influence of physiological significance, preference, and stress on taste codingF31DC010557 · NIDCD · YALE UNIVERSITY · PI RUDENGA, KRISTIN JOY · 2009 to 2011
$52k
NIDCD NIH HHS F31 DC010557NIDCD NIH HHS F31-DC010557-01NIDCD NIH HHS R01 DC006706NIDDK NIH HHS R01 DK085579
6 · The paper itself

Abstract

Controversy exists over whether exposure to artificial sweeteners degrades the predictive relationship between sweet taste and its post-ingestive consequences. Here we tested whether brain response to caloric sucrose is influenced by individual differences in self-reported artificial sweetener use. Twenty-six subjects participated in fMRI scanning while consuming sucrose solutions. A negative correlation between artificial sweetener use and amygdala response to sucrose ingestion was observed. This finding supports the hypothesis that artificial sweetener use may be associated with brain changes that could influence eating behavior.

Indexed as

AdultAmygdalaDietary SucroseFemaleHumansMagnetic Resonance ImagingMaleSurveys and QuestionnairesSweetening AgentsDietary SucroseSweetening Agents

Identifiers

PMID22178008
PMCPMC3289048

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.