ArticleSleep medicine2012
TCRA, P2RY11, and CPT1B/CHKB associations in Chinese narcolepsy.
Article in Sleep medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 53 citations in OpenAlex.
- Evaluation of pitolisant, sodium oxybate, solriamfetol, and modafinil for the management of narcolepsy: a retrospective analysis of the FAERS database.Frontiers in pharmacology · 2024Article
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- Unique transcriptional signatures of sleep loss across independently evolved cavefish populations.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2020Article
- Differences in clinical and genetic characteristics between early- and late-onset narcolepsy in a Han Chinese cohort.Neural regeneration research · 2020Article
- Association between genetic risk scores and risk of narcolepsy: a case-control study.Annals of translational medicine · 2020Article
- Analyzing Functional Pathways and constructing gene-gene network for Narcolepsy based on candidate genes.International journal of medical sciences · 2020Article
- Relationship between T-cell receptor α gene polymorphisms and symptomatic differences in patients with narcolepsy type 1.Chinese medical journal · 2019Article
- Autoimmunity in narcolepsy.Current opinion in pulmonary medicine · 2017Review
- NSFC spurs significant basic research progress of respiratory medicine in China.The clinical respiratory journal · 2017Review
- Beta-amyloid and phosphorylated tau metabolism changes in narcolepsy over time.Sleep & breathing = Schlaf & Atmung · 2016Article
- Identification of the variations in the CPT1B and CHKB genes along with the HLA-DQB1*06:02 allele in Turkish narcolepsy patients and healthy persons.Genetic testing and molecular biomarkers · 2014Article
- The autoimmune basis of narcolepsy.Current opinion in neurobiology · 2013Review
- Genome wide analysis of narcolepsy in China implicates novel immune loci and reveals changes in association prior to versus after the 2009 H1N1 influenza pandemic.PLoS genetics · 2013Article
- Modeling the genetic basis for human sleep disorders in Drosophila.Communicative & integrative biology · 2013Article
- Increased incidence and clinical picture of childhood narcolepsy following the 2009 H1N1 pandemic vaccination campaign in Finland.PloS one · 2012Article
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Authors and funding
15 authors at 4 institutions in 2 countries.
Funding
Abstract
objectivesPolymorphisms in the TCRA and P2RY11, two immune related genes, are associated with narcolepsy in Caucasians and Asians. In contrast, CPT1B/CHKB polymorphisms have only been shown to be associated with narcolepsy in Japanese, with replication in a small group of Koreans. Our aim was to study whether these polymorphisms are associated with narcolepsy and its clinical characteristics in Chinese patients with narcolepsy.
methodsWe collected clinical data on 510 Chinese patients presenting with narcolepsy/hypocretin deficiency. Patients were included either when hypocretin deficiency was documented (CSF hypocretin-1≤110 pg/ml, n=91) or on the basis of the presence of clear cataplexy and HLA-DQB1∗0602 positivity (n=419). Genetic data was compared to typing obtained in 452 controls matched for geographic origin within China. Clinical evaluations included demographics, the Stanford Sleep Inventory (presence and age of onset of each symptom), and Multiple Sleep Latency Test (MSLT) data.
resultsChinese narcolepsy was strongly and dose dependently associated with TCRA (rs1154155C) and P2RY11 (rs2305795A) but not CPT1B/CHKB (rs5770917C) polymorphisms. CPT1B/CHKB polymorphisms were not associated with any specific clinical characteristics. TCRA rs1154155A homozygotes (58 subjects) had a later disease onset, but this was not significant when corrected for multiple comparisons, thus replication is needed. CPT1B/CHKB or P2RY11 polymorphisms were not associated with any specific clinical characteristics.
conclusionsThe study extends on the observation of a strong multiethnic association of polymorphisms in the TCRA and P2RY11 with narcolepsy, but does not confirm the association of CPT1B/CHKB (rs5770917) in the Chinese population.
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