ArticleThe Journal of allergy and clinical immunology2012
Asthma diagnosis and airway bronchodilator response in HIV-infected patients.
Article in The Journal of allergy and clinical immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 39 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pneumocystis in Pathogenesis of HIV-associated Emphysema
Adiposity and Airway Inflammation in HIV-Associated Airway Disease
Implementing, Validating, and Disseminating a Patient-facing Mobile Health Application for HIV Infected and Uninfected Women With Co-morbid Conditions in the Outpatient Setting
Who cites it
39 citing papers in PubMed, 67 citations in OpenAlex.
- Review
- Correlation of High Resolution CT Findings With Lung Function in Adolescents With Perinatally Acquired HIV on Anti-Retroviral Therapy.Pediatric pulmonology · 2025Article
- HIV-associated lung disease.Nature reviews. Disease primers · 2023Review
- Circadian-Coupled Genes Expression and Regulation in HIV-Associated Chronic Obstructive Pulmonary Disease (COPD) and Lung Comorbidities.International journal of molecular sciences · 2023Review
- Health conditions in adults with HIV compared with the general population: A population-based cross-sectional analysis.EClinicalMedicine · 2022Article
- Gene-specific MicroRNA antagonism protects against HIV Tat and TGF-β-mediated suppression of CFTR mRNA and function.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2021Article
- The influence of HIV infection and antiretroviral treatment on pulmonary function in individuals in an urban setting in sub-Saharan Africa.Southern African journal of HIV medicine · 2021Article
- HIV gp120 Induces the Release of Proinflammatory, Angiogenic, and Lymphangiogenic Factors from Human Lung Mast Cells.Vaccines · 2020Article
- Bronchoscopy in severe childhood asthma: Irresponsible or irreplaceable?Pediatric pulmonology · 2020Review
- The impact of HIV on the prevalence of asthma in Uganda: a general population survey.Respiratory research · 2018Article
- Complex association patterns for inflammatory mediators in induced sputum from subjects with asthma.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2018Article
- Pulmonary disease in HIV-infected adults in the era of antiretroviral therapy.AIDS (London, England) · 2018Review
- Lung function in HIV-infected children and adolescents.Pneumonia (Nathan Qld.) · 2018Review
- Long-term pulmonary complications in perinatally HIV-infected youth.The Journal of allergy and clinical immunology · 2017Article
- Lung Function in South African Adolescents Infected Perinatally with HIV and Treated Long-Term with Antiretroviral Therapy.Annals of the American Thoracic Society · 2017Article
- A Novel CD4American journal of respiratory and critical care medicine · 2016Article
- Adiposity influences airway wall thickness and the asthma phenotype of HIV-associated obstructive lung disease: a cross-sectional study.BMC pulmonary medicine · 2016Article
- A cross-sectional, facility based study of comorbid non-communicable diseases among adults living with HIV infection in Zimbabwe.BMC research notes · 2016Article
- Novel relationships of markers of monocyte activation and endothelial dysfunction with pulmonary dysfunction in HIV-infected persons.AIDS (London, England) · 2016Observational
- Clinical Characteristics and Lung Function in Older Children Vertically Infected With Human Immunodeficiency Virus in Malawi.Journal of the Pediatric Infectious Diseases Society · 2016Article
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Authors and funding
14 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundDespite the high prevalence of respiratory symptoms and obstructive lung disease in HIV-infected subjects, the prevalence of bronchodilator reversibility (BDR) and asthma has not been systematically studied during the era of combination antiretroviral therapy (ART).
objectiveWe sought to determine the prevalence of asthma diagnosis and related pulmonary function abnormalities in an HIV-infected cohort and to identify potential mechanisms.
methodsWe performed a cross-sectional analysis of 223 HIV-infected subjects with data on respiratory symptoms and diagnoses, pulmonary function, sputum cell counts, and asthma-related cytokines and chemokines in serum/sputum.
resultsDoctor-diagnosed asthma was present in 46 (20.6%), and BDR (≥200 mL and ≥12% increase in FEV(1) or forced vital capacity) was present in 20 (9.0%) participants. Pulmonary symptoms and function were worse in those with doctor-diagnosed asthma. Doctor-diagnosed asthma was independently associated with female sex (P = .04), body mass index of greater than 29.6 kg/m(2) (vs <29.6 kg/m(2), P = .03), history of bacterial or Pneumocystis pneumonia (P = .01), and not currently taking ART (P = .04) and in univariate analysis with parental history of asthma (n = 180, P = .004). High sputum eosinophil percentages (>2.3% based on the highest decile) were more likely in those with doctor-diagnosed asthma (P = .02) or BDR (P = .02). Doctor-diagnosed asthma tended to be more common with high sputum IL-4 (P = .02) and RANTES (P = .02) levels, whereas BDR was associated with high plasma macrophage inflammatory protein 1α (P = .002) and sputum macrophage inflammatory protein 1β (P = .001) levels.
conclusionAsthma diagnosis and BDR are prevalent in an HIV-infected outpatient cohort, and associations with family history, obesity, allergic inflammation, prior infection, absence of ART, and increased HIV-stimulated cytokines suggest possible mechanisms of HIV-associated asthma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.