SynthesisRespiratory research2011
Nicotinic acetylcholine receptor variants associated with susceptibility to chronic obstructive pulmonary disease: a meta-analysis.
Synthesis in Respiratory research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Increased Frequency of Angiotensin-Converting Enzyme D Allele in Asian Patients With Chronic Obstructive Pulmonary Disease: An Updated Meta-Analysis.The clinical respiratory journal · 2024Pooled it
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- A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.BMC genetics · 2015Trial
- Role of the neurotransmitter-receptor pathway in T-cell tumor immunology and cancer immunotherapy.Acta biochimica et biophysica Sinica · 2026Review
- A novel phenotype imputation method with copula model.BMC bioinformatics · 2024Article
- A computationally efficient clustering linear combination approach to jointly analyze multiple phenotypes for GWAS.PloS one · 2022Article
- Long-term endogenous acetylcholine deficiency potentiates pulmonary inflammation in a murine model of elastase-induced emphysema.Scientific reports · 2021Article
- Inhaled nicotine and lung cancer: Potential role of the nicotinic acetylcholine receptor.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Joint analysis of multiple phenotypes using a clustering linear combination method based on hierarchical clustering.Genetic epidemiology · 2020Article
- A clustering linear combination approach to jointly analyze multiple phenotypes for GWAS.Bioinformatics (Oxford, England) · 2019Article
- Gene fingerprint model for literature based detection of the associations among complex diseases: a case study of COPD.BMC medical informatics and decision making · 2019Article
- Joint Analysis of Multiple Phenotypes in Association Studies based on Cross-Validation Prediction Error.Scientific reports · 2019Article
- A novel genetic marker of decreased inflammation and improved survival after acute myocardial infarction.Basic research in cardiology · 2018Observational
- A hierarchical clustering method for dimension reduction in joint analysis of multiple phenotypes.Genetic epidemiology · 2018Article
- A novel method to test associations between a weighted combination of phenotypes and genetic variants.PloS one · 2018Article
- TwoInternational journal of chronic obstructive pulmonary disease · 2017Article
- Article
- An Adaptive Fisher's Combination Method for Joint Analysis of Multiple Phenotypes in Association Studies.Scientific reports · 2016Article
- Nicotinic acetylcholine receptor expression in human airway correlates with lung function.American journal of physiology. Lung cellular and molecular physiology · 2016Article
- Differential expression analysis for pathways.PLoS computational biology · 2013Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOnly 10-15% of smokers develop chronic obstructive pulmonary disease (COPD) which indicates genetic susceptibility to the disease. Recent studies suggested an association between COPD and polymorphisms in CHRNA coding subunits of nicotinic acetylcholine receptor. Herein, we performed a meta-analysis to clarify the impact of CHRNA variants on COPD.
methodsWe searched Web of Knowledge and Medline from 1990 through June 2011 for COPD gene studies reporting variants on CHRNA. Pooled odds ratios (ORs) were calculated using the major allele or genotype as reference group.
resultsAmong seven reported variants in CHRNA, rs1051730 was finally analyzed with sufficient studies. Totally 3460 COPD and 11437 controls from 7 individual studies were pooled-analyzed. A-allele of rs1051730 was associated with an increased risk of COPD regardless of smoking exposure (pooled OR = 1.26, 95% CI 1.18-1.34, p < 10⁻⁵). At the genotypic level, the ORs gradually increased per A-allele (OR = 1.27 and 1.50 for GA and AA respectively, p < 10⁻⁵). Besides, AA genotype exhibited an association with reduced FEV1% predicted (mean difference 3.51%, 95%CI 0.87-6.16%, p = 0.009) and increased risk of emphysema (OR 1.93, 95%CI 1.29-2.90, p = 0.001).
conclusionsOur findings suggest that rs1051730 in CHRNA is a susceptibility variant for COPD, in terms of both airway obstruction and parenchyma destruction.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.