Evidence map›Paper›PMID 22176938›Full record

ArticleJournal of the American Academy of Child and Adolescent Psychiatry2012

Testing the construct validity of proposed criteria for DSM-5 autism spectrum disorder.

William P L Mandy, Tony Charman, David H Skuse

Abstract readComparative StudyValidation Study
PubMed Publisher
In one paragraph

Article in Journal of the American Academy of Child and Adolescent Psychiatry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

74 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Recognition of emotions in autism: a formal meta-analysis.Journal of autism and developmental disorders · 2013
    Pooled it
  2. Trial
  3. Review
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  5. Article
  6. Review
  7. Article
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  9. Article
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  11. Review
  12. Article
  13. Article
  14. mTOR-Dependent Spine Dynamics in Autism.Frontiers in molecular neuroscience · 2022
    Review
  15. The Diagnosis of Autism: From Kanner to DSM-III to DSM-5 and Beyond.Journal of autism and developmental disorders · 2021
    Review
  16. Article
  17. Molecular Pathways within Autism Spectrum Disorder Endophenotypes.Journal of molecular neuroscience : MN · 2021
    Article
  18. Article
  19. Article
  20. Article

14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

William P L MandyResearch Department of Clinical, Health and Educational Psychology, University College London, London, UK. w.mandy@ucl.ac.uk
Tony Charman
David H Skuse

Funding

Medical Research Council
6 · The paper itself

Abstract

objectiveTo use confirmatory factor analysis to test the construct validity of the proposed DSM-5 symptom model of autism spectrum disorder (ASD), in comparison to alternative models, including that described in DSM-IV-TR.

methodParticipants were 708 verbal children and young persons (mean age, 9.5 years) with mild to severe autistic difficulties. Autistic symptoms were measured using the Developmental, Dimensional and Diagnostic interview (3Di). The fit of the two-factor DSM-5 model, which has a social communication and a restricted, repetitive behavior (RRB) factor, was compared with that of alternative models. In one half of the sample, properties of the DSM-5 model were examined to investigate the validity of specific diagnostic criteria, informing the development of a better fitting DSM-5 model. This was then cross-validated in the remaining "hold-out" half of the sample; and its stability was tested across groups defined by age, sex, and symptom severity.

resultsThe DSM-5 model was superior to the three-factor DSM-IV-TR model. It was improved by the removal of items measuring "play and imagination" and "stereotyped and repetitive use of language." A scale measuring sensory abnormalities was added to the model, and loaded onto its RRB factor. This DSM-5 model fit well in the hold-out sample; was stable across age and sex; and fit adequately in those with clinical and sub-threshold autistic presentations.

conclusionsAmong higher-functioning individuals, ASD is a dyad, not a triad, with distinct social communication and repetitive behavior dimensions. As suggested in the proposed DSM-5 criteria, sensory abnormalities are part of the RRB symptom cluster.

Indexed as

Diagnostic and Statistical Manual of Mental DisordersAdolescentAdultChildChild Development Disorders, PervasiveChild, PreschoolFemaleHumansMaleModels, StatisticalNeuropsychological TestsPhenotypeSeverity of Illness IndexYoung Adult

Identifiers

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.