ArticleVirology journal2011
The interaction between the PARP10 protein and the NS1 protein of H5N1 AIV and its effect on virus replication.
Article in Virology journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
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- DELTEX E3 ligases ubiquitylate ADP-ribosyl modification on nucleic acids.Nucleic acids research · 2024Article
- Roles of ADP-Ribosylation during Infection Establishment byPathogens (Basel, Switzerland) · 2023Review
- Intracellular mono-ADP-ribosyltransferases at the host-virus interphase.Cellular and molecular life sciences : CMLS · 2022Review
- NAD+-consuming enzymes in immune defense against viral infection.The Biochemical journal · 2021Review
- The Antiviral Activities of Poly-ADP-Ribose Polymerases.Viruses · 2021Review
- Brain tissue transcriptomic analysis of SIV-infected macaques identifies several altered metabolic pathways linked to neuropathogenesis and poly (ADP-ribose) polymerases (PARPs) as potential therapeutic targets.Journal of neurovirology · 2021Article
- NADFrontiers in molecular biosciences · 2021Review
- Genome-Wide Association Studies for the Concentration of Albumin in Colostrum and Serum in Chinese Holstein.Animals : an open access journal from MDPI · 2020Article
- Comparative Transcriptome Analysis Reveals the Intensive Early Stage Responses of Host Cells to SARS-CoV-2 Infection.Frontiers in microbiology · 2020Article
- MicroRNA expression profiles from HEK293 cells expressing H5N1 avian influenza virus non-structural protein 1.Innate immunity · 2019Article
- Article
- Identification of NS1 domains of avian H5N1 influenza virus which influence the interaction with the NOLC1 protein.Virus genes · 2015Article
- The influenza virus NS1 protein as a therapeutic target.Antiviral research · 2013Review
- DNMT gene expression and methylome in Marek's disease resistant and susceptible chickens prior to and following infection by MDV.Epigenetics · 2013Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDuring the process that AIV infect hosts, the NS1 protein can act on hosts, change corresponding signal pathways, promote the translation of virus proteins and result in virus replication.
resultsIn our study, we found that PARP domain and Glu-rich region of PARP10 interacted with NS1, and the presence of NS1 could induce PARP10 migrate from cytoplasm to nucleus. NS1 high expression could reduce the endogenous PARP10 expression. Cell cycle analysis showed that with inhibited PARP10 expression, NS1 could induce cell arrest in G2-M stage, and the percentage of cells in G2-M stage rise from the previous 10%-45%, consistent with the cell proliferation result. Plague forming unit measurement showed that inhibited PARP10 expression could help virus replication.
conclusionsIn a word, our results showed that NS1 acts on host cells and PARP10 plays a regulating role in virus replication.
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