Evidence map›Paper›PMID 22176889›Full record

ArticleBMC pediatrics2011

Birth weight for gestational age norms for a large cohort of infants born to HIV-negative women in Botswana compared with norms for U.S.-born black infants.

Lynn T Matthews, Heather J Ribaudo, Natasha K Parekh, Jennifer Y Chen, Kelebogile Binda, Anthony Ogwu, Joseph Makhema, Sajini Souda, Shahin Lockman, Max Essex and 1 more

Open access · goldAbstract readComparative StudyMulticenter Study
In one paragraph

Article in BMC pediatrics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
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  9. Birth weight and asthma incidence by asthma phenotype pattern in a racially diverse cohort followed through adolescence.The Journal of asthma : official journal of the Association for the Care of Asthma · 2015
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 2 countries.

Lynn T MatthewsBeth Israel Deaconess Medical Center, Division of Infectious Disease, Boston, MA 02115, USA. ltmatthe@bidmc.harvard.edu
Heather J Ribaudo
Natasha K Parekh
Jennifer Y Chen
Kelebogile Binda
Anthony Ogwu
Joseph Makhema
Sajini Souda
Shahin Lockman
Max Essex
Roger L Shapiro
Botswana Harvard AIDS Institute Partnership · BWHarvard University · USBeth Israel Deaconess Medical Center · USBoston University · USBrigham and Women's Hospital · USUniversity of Miami · US

Funding

The impact of HIV viral diversity and cellular immunity on HIV pathogenesisP30AI060354 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI ROBERT A. PARKER · 2004 to 2026
$94.4M
Periconception HIV risk reduction for HIV-discordant couples in UgandaK23MH095655 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI MATTHEWS, LYNN T · 2011 to 2015
$854k
NIAID NIH HHS AI060354NIAID NIH HHS P30 AI060354NIMH NIH HHS K23 MH095655NIMH NIH HHS MH095655
6 · The paper itself

Abstract

backgroundStandard values for birth weight by gestational age are not available for sub-Saharan Africa, but are needed to evaluate incidence and risk factors for intrauterine growth retardation in settings where HIV, antiretrovirals, and other in utero exposures may impact birth outcomes.

methodsBirth weight data were collected from six hospitals in Botswana. Infants born to HIV-negative women between 26-44 weeks gestation were analyzed to construct birth weight for gestational age charts. These data were compared with published norms for black infants in the United States.

resultsDuring a 29 month period from 2007-2010, birth records were reviewed in real-time from 6 hospitals and clinics in Botswana. Of these, 11,753 live infants born to HIV-negative women were included in the analysis. The median gestational age at birth was 39 weeks (1st quartile 38, 3rd quartile 40 weeks), and the median birth weight was 3100 grams (1st quartile 2800, 3rd quartile 3400 grams). We constructed estimated percentile curves for birth weight by gestational age which demonstrate increasing slope during the third trimester and leveling off beyond 40 weeks. Compared with black infants in the United States, Botswana-born infants had lower median birth weight for gestational age from weeks 37 through 42 (p < .02).

conclusionsWe present birth weight for gestational age norms for Botswana, which are lower at term than norms for black infants in the United States. These findings suggest the importance of regional birth weight norms to identify and define risk factors for higher risk births. These data serve as a reference for Botswana, may apply to southern Africa, and may help to identify infants at risk for perinatal complications and inform comparisons among infants exposed to HIV and antiretrovirals in utero.

Indexed as

Birth WeightBlack or African AmericanGestational AgeHIV SeronegativityBirth CertificatesBotswanaFemaleHIVHIV AntibodiesHIV InfectionsHumansInfant, NewbornPregnancyPregnancy Complications, InfectiousRisk FactorsUnited StatesHIV Antibodies

Identifiers

PMID22176889
PMCPMC3271964
OpenAlexW2099368664

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.