ArticleThe international journal of neuropsychopharmacology2012
Dopamine D1 receptor involvement in latent inhibition and overshadowing.
Article in The international journal of neuropsychopharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 17 citations in OpenAlex.
- Adolescent male and female rats show enhanced latent inhibition of conditioned fear compared to adult rats.Frontiers in behavioral neuroscience · 2025Article
- Anterior thalamic nuclei, but not retrosplenial cortex, lesions abolish latent inhibition in rats.Behavioral neuroscience · 2018Article
- Instrumental conditioning for food reinforcement in the spontaneously hypertensive rat model of attention deficit hyperactivity disorder.BMC research notes · 2017Article
- Scopolamine Impairs Appetitive But Not Aversive Trace Conditioning: Role of the Medial Prefrontal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- The dopamine D1 receptor agonist SKF81297 has dose-related effects on locomotor activity but is without effect in a CER trace conditioning procedure conducted with two versus four trials.Learning and motivation · 2016Article
- Phasic dopamine release in the medial prefrontal cortex enhances stimulus discrimination.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Involvement of D1 and D2 dopamine receptor in the retrieval processes in latent inhibition.Psychopharmacology · 2015Article
- Dopamine D1 receptor stimulation modulates the formation and retrieval of novel object recognition memory: Role of the prelimbic cortex.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2015Article
- Dopaminergic modulation of appetitive trace conditioning: the role of D1 receptors in medial prefrontal cortex.Psychopharmacology · 2015Article
- Potentiation of latent inhibition by haloperidol and clozapine is attenuated in Dopamine D2 receptor (Drd-2)-deficient mice: do antipsychotics influence learning to ignore irrelevant stimuli via both Drd-2 and non-Drd-2 mechanisms?Journal of psychopharmacology (Oxford, England) · 2014Article
- From attention to memory along the dorsal-ventral axis of the medial prefrontal cortex: some methodological considerations.Frontiers in systems neuroscience · 2014Review
- D-amphetamine and antipsychotic drug effects on latent inhibition in mice lacking dopamine D2 receptors.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2013Article
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3 authors at 1 institution in 1 country.
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Abstract
Latent inhibition (LI) manifests as poorer conditioning to a stimulus that has previously been experienced without consequence. There is good evidence of dopaminergic modulation of LI, as the effect is reliably disrupted by the indirect dopamine (DA) agonist amphetamine. The disruptive effects of amphetamine on LI are reversed by both typical and atypical antipsychotics, which on their own are able to facilitate LI. However, the contribution of different DA receptors to these effects is poorly understood. Amphetamine effects on another stimulus selection procedure, overshadowing, have been suggested to be D1-mediated. Thus, in the current experiments, we systematically investigated the role of D1 receptors in LI. First, we tested the ability of the full D1 agonist SKF 81297 to abolish LI and compared the effects of this drug on LI and overshadowing. Subsequently, we examined whether the D1 antagonist SCH 23390 can lead to the emergence of LI under conditions that do not produce the effect in normal animals (weak pre-exposure). Finally, we tested the ability of SCH 23390 to block amphetamine-induced disruption of LI. We found little evidence that direct stimulation of D1 receptors abolishes LI (although there was some attenuation of LI at 0.4 mg/kg SKF 81297). Similarly, SCH 23390 failed to enhance LI. However, SCH 23390 did block amphetamine-induced disruption of LI. These data indicate that, while LI may be unaffected by selective manipulation of activity at D1 receptors, the effects of amphetamine on LI are to some extent dependent on actions at D1 receptors.
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