Evidence map›Paper›PMID 22176721›Full record

ArticlePsychophysiology2012

Spatiotemporal and frequency domain analysis of auditory paired stimuli processing in schizophrenia and bipolar disorder with psychosis.

Jordan P Hamm, Lauren E Ethridge, John R Shapiro, Michael C Stevens, Nashaat N Boutros, Ann T Summerfelt, Matcheri S Keshavan, John A Sweeney, Godfrey Pearlson, Carol A Tamminga and 2 more

Abstract readComparative Study
In one paragraph

Article in Psychophysiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 1 country.

Jordan P HammDepartment of Psychology, University of Georgia, Athens, Georgia 30602-3013, USA.
Lauren E Ethridge
John R Shapiro
Michael C Stevens
Nashaat N Boutros
Ann T Summerfelt
Matcheri S Keshavan
John A Sweeney
Godfrey Pearlson
Carol A Tamminga
Gunvant Thaker
Brett A Clementz
University of Georgia · USUniversity of Mary · USBeth Israel Deaconess Medical Center · USHartford Financial Services (United States)Institute for Community Living · USSouthwestern Medical Center · USThe University of Texas Southwestern Medical Center · USWayne State University · US

Funding

Bipolar & Schizophrenia Consortium for Parsing Intermediate PhenotypesR01MH077851 · NIMH · UT SOUTHWESTERN MEDICAL CENTER · PI TAMMINGA, CAROL A · 2007 to 2019
$7.8M
Bipolar & Schizophrenia Consortium for Parsing Intermediate PhenotypesR01MH077945 · NIMH · YALE UNIVERSITY · PI PEARLSON, GODFREY D · 2007 to 2019
$7.6M
Stability of Biotypes: a Longitudinal EvaluationR01MH078113 · NIMH · WAYNE STATE UNIVERSITY · PI KESHAVAN, MATCHERI S. · 2007 to 2019
$6.2M
Bipolar & Schizophrenia Consortium for Parsing Intermediate PhenotypesR01MH077862 · NIMH · UT SOUTHWESTERN MEDICAL CENTER · PI SWEENEY, JOHN A · 2007 to 2010
$3.1M
Neural mechanisms for antisaccade errors among schizophrenia familiesR01MH085485 · NIMH · UNIVERSITY OF GEORGIA · PI CLEMENTZ, BRETT A · 2009 to 2013
$1.4M
NIMH NIH HHS R01 MH077851NIMH NIH HHS R01 MH077862NIMH NIH HHS R01 MH077945NIMH NIH HHS R01 MH078113NIMH NIH HHS R01 MH085485
6 · The paper itself

Abstract

Individuals with schizophrenia (SZ) or bipolar disorder with psychosis (BPP) may share neurophysiological abnormalities as measured in auditory paired-stimuli paradigms with electroencephalography (EEG). Such investigations have been limited, however, by quantifying only event-related potential peaks and/or broad frequency bands at limited scalp locations without considering possible mediating factors (e.g., baseline differences). Results from 64-sensor EEG collected in 180 age- and gender-matched participants reveal (i) accentuated prestimulus gamma oscillations and (ii) reduced P2 amplitudes and theta/alpha oscillations to S1 among participants with both SZ and BPP. Conversely, (iii) N1s in those with SZ to S1 were reduced compared to healthy volunteers and those with BPP, whereas (iv) beta range oscillations 200-300 ms following S2 were accentuated in those with BPP but not those with SZ. Results reveal a pattern of both unique and shared neurophysiological phenotypes occurring within major psychotic diagnoses.

Indexed as

Schizophrenic PsychologyAcoustic StimulationAdolescentAdultAuditory PerceptionBeta RhythmBipolar DisorderData Interpretation, StatisticalDiagnostic and Statistical Manual of Mental DisordersDiscriminant AnalysisElectroencephalographyFemaleHumansMaleMiddle AgedPhenotype

Identifiers

PMID22176721
PMCPMC3309114
OpenAlexW2116944142

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.