Evidence map›Paper›PMID 22174954›Full record

ArticlePloS one2011

Small protein-mediated quorum sensing in a Gram-negative bacterium.

Sang-Wook Han, Malinee Sriariyanun, Sang-Won Lee, Manoj Sharma, Ofir Bahar, Zachary Bower, Pamela C Ronald

RetractedOpen access · goldAbstract readRetracted Publication
In one paragraph

Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 38 citations in OpenAlex.

  1. Review
  2. Quorum Sensing Signaling and Quenching in the Multidrug-Resistant PathogenFrontiers in cellular and infection microbiology · 2018
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Sang-Wook HanDepartment of Plant Pathology and the Genome Center, University of California Davis, Davis, California, United States of America.
Malinee Sriariyanun
Sang-Won Lee
Manoj Sharma
Ofir Bahar
Zachary Bower
Pamela C Ronald
University of California, Davis · USKyung Hee University · KR

Funding

Receptor Kinase-Mediated Signaling in the Innate Immune ResponseR01GM055962 · NIGMS · UNIVERSITY OF CALIFORNIA DAVIS · PI RONALD, PAMELA C · 1999 to 2013
$2.9M
NIGMS NIH HHS GM55962NIGMS NIH HHS R01 GM055962PHS HHS 2010-0026679PHS HHS PJ0080982011
6 · The paper itself

Abstract

The rice XA21 pattern recognition receptor binds a type I secreted sulfated peptide, called axY(S)22, derived from the Ax21 (activator of XA21-mediated immunity) protein. The conservation of Ax21 in all sequenced Xanthomonas spp. and closely related genera suggests that Ax21 serves a key biological function. Here we show that the predicted N-terminal sequence of Ax21 is cleaved prior to secretion outside the cell and that mature Ax21 serves as a quorum sensing (QS) factor in Xanthomonas oryzae pv. oryzae. Ax21-mediated QS controls motility, biofilm formation and virulence. We provide genetic evidence that the Xoo RaxH histidine kinase serves as the bacterial receptor for Ax21. This work establishes a critical role for small protein-mediated QS in a Gram-negative bacterium.

Indexed as

Quorum SensingBacterial ProteinsBiofilmsGenome, BacterialGram-Negative BacteriaRecombinant ProteinsTranscriptomeVirulenceBacterial ProteinsRecombinant Proteins

Identifiers

PMID22174954
PMCPMC3236232
OpenAlexW2080070774

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.