SynthesisPloS one2011
Cigarette smoking and p16INK4α gene promoter hypermethylation in non-small cell lung carcinoma patients: a meta-analysis.
Synthesis in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 4 of them syntheses that pooled it.
What it found
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Who cites it
15 citing papers in PubMed, 4 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Meta-analyses of gene methylation and smoking behavior in non-small cell lung cancer patients.Scientific reports · 2015Pooled it
- CDKN2A/p16 inactivation mechanisms and their relationship to smoke exposure and molecular features in non-small-cell lung cancer.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2013Pooled it
- The prognostic value of epigenetic silencing of p16 gene in NSCLC patients: a systematic review and meta-analysis.PloS one · 2013Pooled it
- Association between P(16INK4a) promoter methylation and non-small cell lung cancer: a meta-analysis.PloS one · 2013Pooled it
- Epigenetics of Chronic Stress: Mechanisms and Health Impacts.Current genomics · 2025Review
- Can social adversity alter the epigenome, trigger oral disease, and affect future generations?Irish journal of medical science · 2024Review
- Article
- Tissue P16 is Associated with Smoking Status among Indonesian Nasopharyngeal Carcinoma Subjects.Asian Pacific journal of cancer prevention : APJCP · 2019Article
- Cellular senescence and senescence-associated secretory phenotype: comparison of idiopathic pulmonary fibrosis, connective tissue disease-associated interstitial lung disease, and chronic obstructive pulmonary disease.Journal of thoracic disease · 2019Article
- Role of mucosal high-risk human papillomavirus types in head and neck cancers in Romania.PloS one · 2018Article
- Rotating night work, lifestyle factors, obesity and promoter methylation in BRCA1 and BRCA2 genes among nurses and midwives.PloS one · 2017Article
- Aberrant gene promoter methylation of p16, FHIT, CRBP1, WWOX, and DLC-1 in Epstein-Barr virus-associated gastric carcinomas.Medical oncology (Northwood, London, England) · 2015Article
- Human papillomavirus DNA and p16 expression in Japanese patients with oropharyngeal squamous cell carcinoma.Cancer medicine · 2013Article
- Autophagic protein Beclin 1 serves as an independent positive prognostic biomarker for non-small cell lung cancer.PloS one · 2013Article
- New P16 Expression Criteria Predict Lymph Node Metastasis in Patients With Non-small Cell Lung Cancer.In vivo (Athens, Greece)Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAberrant methylation of promoter DNA and transcriptional repression of specific tumor suppressor genes play an important role in carcinogenesis. Recently, many studies have investigated the association between cigarette smoking and p16(INK4α) gene hypermethylation in lung cancer, but could not reach a unanimous conclusion. METHODS AND
findingsNineteen cross-sectional studies on the association between cigarette smoking and p16(INK4α) methylation in surgically resected tumor tissues from non-small cell lung carcinoma (NSCLC) patients were identified in PubMed database until June 2011. For each study, a 2×2 cross-table was extracted. In total, 2,037 smoker and 765 nonsmoker patients were pooled with a fixed-effects model weighting for the inverse of the variance. Overall, the frequency of p16(INK4α) hypermethylation was higher in NSCLC patients with smoking habits than that in non-smoking patients (OR = 2.25, 95% CI = 1.81-2.80). The positive association between cigarette smoking and p16(INK4α) hypermethylation was similar in adenocarcinoma and squamous-cell carcinoma. In the stratified analyses, the association was stronger in Asian patients and in the studies with larger sample sizes.
conclusionCigarette smoking is positively correlated to p16(INK4α) gene hypermethylation in NSCLC patients.
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