ArticlePloS one2011
Genome-wide association study of hepatocellular carcinoma in Southern Chinese patients with chronic hepatitis B virus infection.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 65 citations in OpenAlex.
- Effects of sex and generation on hepatitis B viral load in families with hepatocellular carcinoma.World journal of gastroenterology · 2017Trial
- Genetic Susceptibility to Hepatocellular Carcinoma in Patients with Chronic Hepatitis Virus Infection.Viruses · 2023Review
- HIV-1-Mediated Acceleration of Oncovirus-Related Non-AIDS-Defining Cancers.Biomedicines · 2022Review
- Genetic susceptibility to hepatocellular carcinoma in chromosome 22q13.31, findings of a genome-wide association study.JGH open : an open access journal of gastroenterology and hepatology · 2021Article
- The association of lncRNA SNPs and SNPs-environment interactions based on GWAS with HBV-related HCC risk and progression.Molecular genetics & genomic medicine · 2021Article
- Fine Mapping of the MHC Region Identifies Novel Variants Associated with HBV-Related Hepatocellular Carcinoma in Han Chinese.Journal of hepatocellular carcinoma · 2021Article
- Knowledge-based analyses reveal new candidate genes associated with risk of hepatitis B virus related hepatocellular carcinoma.BMC cancer · 2020Article
- Locus 5p13.1 may be associated with the selection of cancer-related HBV core promoter mutations.International journal of medical sciences · 2019Article
- Host genetic factors affecting hepatitis B infection outcomes: Insights from genome-wide association studies.World journal of gastroenterology · 2018Review
- Host and Viral Genetic Variation in HBV-Related Hepatocellular Carcinoma.Frontiers in genetics · 2018Review
- Article
- Viral hepatitis and hepatocellular carcinoma: etiology and management.Journal of gastrointestinal oncology · 2017Review
- Nonsyndromic cleft lip with or without cleft palate and cancer: Evaluation of a possible common genetic background through the analysis of GWAS data.Genomics data · 2016Article
- Prediction models of hepatocellular carcinoma development in chronic hepatitis B patients.World journal of gastroenterology · 2016Review
- Association of the GLB1 rs4678680 genetic variant with risk of HBV-related hepatocellular carcinoma.Oncotarget · 2016Article
- Integrative Functional Genomics Implicates EPB41 Dysregulation in Hepatocellular Carcinoma Risk.American journal of human genetics · 2016Article
- Host nucleotide polymorphism in hepatitis B virus-associated hepatocellular carcinoma.World journal of hepatology · 2016Review
- Genetic variations in STAT4,C2,HLA-DRB1 and HLA-DQ associated with risk of hepatitis B virus-related liver cirrhosis.Scientific reports · 2015Article
- Molecular profiling of liver tumors: classification and clinical translation for decision making.Seminars in liver disease · 2014Review
- Common variants on Xq28 conferring risk of schizophrenia in Han Chinese.Schizophrenia bulletin · 2014Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
One of the most relevant risk factors for hepatocellular carcinoma (HCC) development is chronic hepatitis B virus (HBV) infection, but only a fraction of chronic HBV carriers develop HCC, indicating that complex interactions among viral, environmental and genetic factors lead to HCC in HBV-infected patients. So far, host genetic factors have incompletely been characterized. Therefore, we performed a genome-wide association (GWA) study in a Southern Chinese cohort consisting of 95 HBV-infected HCC patients (cases) and 97 HBV-infected patients without HCC (controls) using the Illumina Human610-Quad BeadChips. The top single nucleotide polymorphisms (SNPs) were then validated in an independent cohort of 500 cases and 728 controls. 4 SNPs (rs12682266, rs7821974, rs2275959, rs1573266) at chromosome 8p12 showed consistent association in both the GWA and replication phases (OR(combined) = 1.31-1.39; p(combined) = 2.71 × 10(-5)-5.19 × 10(-4); PAR(combined) = 26-31%). We found a 2.3-kb expressed sequence tag (EST) in the region using in-silico data mining and verified the existence of the full-length EST experimentally. The expression level of the EST was significantly reduced in human HCC tumors in comparison to the corresponding non-tumorous liver tissues (P<0.001). Results from sequence analysis and in-vitro protein translation study suggest that the transcript might function as a long non-coding RNA. In summary, our study suggests that variations at chromosome 8p12 may promote HCC in patients with HBV. Further functional studies of this region may help understand HBV-associated hepatocarcinogenesis.
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