ArticlePloS one2011
Convergent evidence from multimodal imaging reveals amygdala abnormalities in schizophrenic patients and their first-degree relatives.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 4 of them syntheses that pooled it.
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Who cites it
28 citing papers in PubMed, 4 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- A meta-analysis and systematic review of single vs. multimodal neuroimaging techniques in the classification of psychosis.Molecular psychiatry · 2023Pooled it
- Brain structural correlates of familial risk for mental illness: a meta-analysis of voxel-based morphometry studies in relatives of patients with psychotic or mood disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Pooled it
- Dysconnectivity of Multiple Brain Networks in Schizophrenia: A Meta-Analysis of Resting-State Functional Connectivity.Frontiers in psychiatry · 2019Pooled it
- Dysfunction of Large-Scale Brain Networks in Schizophrenia: A Meta-analysis of Resting-State Functional Connectivity.Schizophrenia bulletin · 2018Pooled it
- Diazepam modulates hippocampal CA1 functional connectivity in people at clinical high-risk for psychosis.Psychological medicine · 2025Trial
- Subcortical brain abnormalities and cognitive function in individuals with psychosis and their unaffected relatives: A normative modeling approach.Schizophrenia research · 2025Article
- Connecting genomic results for psychiatric disorders to human brain cell types and regions reveals convergence with functional connectivity.medRxiv : the preprint server for health sciences · 2024Article
- Amygdala fMRI-A Critical Appraisal of the Extant Literature.Neuroscience insights · 2024Review
- Amygdala signal abnormality and cognitive impairment in drug-naïve schizophrenia.BMC psychiatry · 2023Article
- Impairment in acquisition of conditioned fear in schizophrenia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Neural Indicators of Fatigue in Chronic Diseases: A Systematic Review of MRI Studies.Diagnostics (Basel, Switzerland) · 2018Review
- Enhanced temporal variability of amygdala-frontal functional connectivity in patients with schizophrenia.NeuroImage. Clinical · 2018Article
- Disruptions in the left frontoparietal network underlie resting state endophenotypic markers in schizophrenia.Human brain mapping · 2017Article
- Multimodal fusion of brain imaging data: A key to finding the missing link(s) in complex mental illness.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2016Article
- Corticolimbic dysfunction during facial and prosodic emotional recognition in first-episode psychosis patients and individuals at ultra-high risk.NeuroImage. Clinical · 2016Article
- Grey matter, an endophenotype for schizophrenia? A voxel-based morphometry study in siblings of patients with schizophrenia.Journal of psychiatry & neuroscience : JPN · 2015Article
- Does neuroanatomy account for superior temporal dysfunction in early psychosis? A multimodal MRI investigation.Journal of psychiatry & neuroscience : JPN · 2015Article
- Function-structure associations of the brain: evidence from multimodal connectivity and covariance studies.NeuroImage · 2014Review
- Amygdala connectivity differs among chronic, early course, and individuals at risk for developing schizophrenia.Schizophrenia bulletin · 2014Article
- Similar and different gray matter deficits in schizophrenia patients and their unaffected biological relatives.Frontiers in psychiatry · 2013Review
Corrections and comments
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Authors and funding
15 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundShared neuropathological features between schizophrenic patients and their first-degree relatives have potential as indicators of genetic vulnerability to schizophrenia. We sought to explore genetic influences on brain morphology and function in schizophrenic patients and their relatives.
methodsUsing a multimodal imaging strategy, we studied 33 schizophrenic patients, 55 of their unaffected parents, 30 healthy controls for patients, and 29 healthy controls for parents with voxel-based morphometry of structural MRI scans and functional connectivity analysis of resting-state functional MRI data.
resultsSchizophrenic patients showed widespread gray matter reductions in the bilateral frontal cortices, bilateral insulae, bilateral occipital cortices, left amygdala and right thalamus, whereas their parents showed more localized reductions in the left amygdala, left thalamus and right orbitofrontal cortex. Patients and their parents shared gray matter loss in the left amygdala. Further investigation of the resting-state functional connectivity of the amygdala in the patients showed abnormal functional connectivity with the bilateral orbitofrontal cortices, bilateral precunei, bilateral dorsolateral frontal cortices and right insula. Their parents showed slightly less, but similar changes in the pattern in the amygdala connectivity. Co-occurrences of abnormal connectivity of the left amygdala with the left orbitofrontal cortex, right dorsolateral frontal cortex and right precuneus were observed in schizophrenic patients and their parents.
conclusionsOur findings suggest a potential genetic influence on structural and functional abnormalities of the amygdala in schizophrenia. Such information could help future efforts to identify the endophenotypes that characterize the complex disorder of schizophrenia.
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