ArticlePloS one2011
Premature decline of serum total testosterone in HIV-infected men in the HAART-era.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
54 citing papers in PubMed, 2 syntheses or guidelines pooled it, 139 citations in OpenAlex.
- Pooled it
- Outcomes of androgen replacement therapy in adult male hypogonadism: recommendations from the Italian society of endocrinology.Journal of endocrinological investigation · 2015Pooled it
- Reliability of calcium-phosphorus (Ca/P) ratio as a new, accurate and inexpensive tool in the diagnosis of some Ca-P disorders.Journal of endocrinological investigation · 2019Trial
- Gonadal and sexual function in men living with HIV: insights from a single-centre study.Journal of endocrinological investigation · 2025Article
- Prevalence of erectile dysfunction and associated factors among newly diagnosed ART naïve men living with HIV: a cross sectional study in Mwanza, Northwestern Tanzania.Frontiers in urology · 2025Article
- Article
- Incidence of prostate cancer in Medicaid beneficiaries with and without HIV in 2001-2015 in 14 states.AIDS care · 2024Article
- Sarcopenic obesity and reduced BMD in young men living with HIV: body composition and sex steroids interplay.Journal of endocrinological investigation · 2024Observational
- SHBG, Free Testosterone, and Type 2 Diabetes Risk in Middle-aged African Men: A Longitudinal Study.Journal of the Endocrine Society · 2024Article
- Serum gonadal hormones levels and hypogonadism in ART naïve newly diagnosed HIV infected adult males in Mwanza, Tanzania.BMC endocrine disorders · 2024Article
- Prevalence of Hypogonadism and Associated Risk Factors among Newly Diagnosed ART Naïve HIV-Infected Males in Mwanza, Tanzania.International journal of endocrinology · 2024Article
- Incidence of erectile dysfunction among middle-aged and aging sexual minority men living with or without HIV.Frontiers in public health · 2024Article
- Down regulation of the inverse relationship between parathyroid hormone and irisin in male vitamin D-sufficient HIV patients.Journal of endocrinological investigation · 2023Article
- Viruses and Endocrine Diseases.Microorganisms · 2023Review
- New perspectives in functional hypogonadotropic hypogonadism: beyond late onset hypogonadism.Frontiers in endocrinology · 2023Review
- Update on acquired hypogonadism in men living with HIV: pathogenesis, clinic, and treatment.Frontiers in endocrinology · 2023Review
- Article
- Article
- Secondary Osteoporosis and Metabolic Bone Diseases.Journal of clinical medicine · 2022Review
- Impact of hypogonadism on bone mineral density and vertebral fractures in HIV-infected men.Journal of endocrinological investigation · 2022Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTestosterone (T) deficiency remains a poorly understood issue in men with Human Immunodeficiency Virus (HIV). We investigated the gonadal status in HIV-infected men in order to characterize T deficiency and to identify predictive factors for low serum T. METHODOLOGY/PRINCIPAL
findingsWe performed a cross-sectional, observational study on 1325 consecutive HIV male outpatients, most of them having lipodystrophy. Serum total T<300 ng/dL was used as the threshold for biochemical T deficiency. Morning serum total T, luteinizing hormone (LH), estradiol, HIV parameters, and body composition parameters by CT-scan and Dual-Energy-X-ray-Absorptiometry were measured in each case. Sexual behavior was evaluated in a subset of 247 patients. T deficiency was found in 212 subjects, especially in the age range 40-59, but was frequent even in younger patients. T deficiency occurred mainly in association with low/normal serum LH. Adiposity was higher in subjects with T deficiency (p<0.0001) and both visceral adipose tissue and body mass index were the main negative predictors of serum total T. Osteoporosis and erectile dysfunction were present in a similar percentage in men with or without T deficiency. CONCLUSIONS/SIGNIFICANCE: Premature decline of serum T is common (16%) among young/middle-aged HIV-infected men and is associated with inappropriately low/normal LH and increased visceral fat. T deficiency occurs at a young age and may be considered an element of the process of premature or accelerated aging known to be associated with HIV infection. The role of HIV and/or HIV infection treatments, as well as the role of the general health state on the gonadal axis, remains, in fact, to be elucidated. Due to the low specificity of signs and symptoms of hypogonadism in the context of HIV, caution is needed in the diagnosis of hypogonadism in HIV-infected men with biochemical low serum T levels.
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Registered trials
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