ArticlePloS one2011
Viscoelastic transition and yield strain of the folded protein.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- On the free energy of protein folding in optical tweezers experiments.Biophysical reviews · 2025Review
- On the distance to the transition state of protein folding in optical tweezers experiments.Biophysical reviews · 2025Review
- Article
- Polymer Dynamics in Glycerol-Water Mixtures.Molecules (Basel, Switzerland) · 2023Article
- A proteome scale study reveals how plastic surfaces and agitation promote protein aggregation.Scientific reports · 2023Article
- Viscoelasticity Acts as a Marker for Tumor Extracellular Matrix Characteristics.Frontiers in cell and developmental biology · 2021Review
- Mechanical properties of BiP protein determined by nano-rheology.Protein science : a publication of the Protein Society · 2018Article
- The role of momentum transfer during incoherent neutron scattering is explained by the energy landscape model.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Article
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2 authors.
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Abstract
For proteins, the mechanical properties of the folded state are directly related to function, which generally entails conformational motion. Through sub-Angstrom resolution measurements of the AC mechanical susceptibility of a globular protein we describe a new fundamental materials property of the folded state. For increasing amplitude of the forcing, there is a reversible transition from elastic to viscoelastic response. At fixed frequency, the amplitude of the deformation is piecewise linear in the force, with different slopes in the elastic and viscoelastic regimes. Effectively, the protein softens beyond a yield point defined by this transition. We propose that ligand induced conformational changes generally operate in this viscoelastic regime, and that this is a universal property of the folded state.
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Registered trials
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