ArticleJournal of biomedicine & biotechnology2011
Antiobesity and hypoglycaemic effects of aqueous extract of Ibervillea sonorae in mice fed a high-fat diet with fructose.
Article in Journal of biomedicine & biotechnology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 40 citations in OpenAlex.
- Antihyperglycemic Effects and Molecular Mechanisms ofPlants (Basel, Switzerland) · 2026Review
- Selected Species of the Cucurbitaceae Family Used in Mexico for the Treatment of Diabetes Mellitus.Molecules (Basel, Switzerland) · 2022Review
- Antidiabetic Activity ofEvidence-based complementary and alternative medicine : eCAM · 2021Article
- Kojic acid repurposing as a pancreatic lipase inhibitor and the optimization of its production from a local Aspergillus oryzae soil isolate.BMC biotechnology · 2020Article
- Molecules Isolated from Mexican Hypoglycemic Plants: A Review.Molecules (Basel, Switzerland) · 2020Review
- UP601, a standardized botanical composition composed of Morus alba, Yerba mate and Magnolia officinalis for weight loss.BMC complementary and alternative medicine · 2017Article
- Evaluation of Hypoglycemic and Genotoxic Effect of Polyphenolic Bark Extract fromEvidence-based complementary and alternative medicine : eCAM · 2016Article
- Pharmacological and Genotoxic Properties of Polyphenolic Extracts of Cedrela odorata L. and Juglans regia L. Barks in Rodents.Evidence-based complementary and alternative medicine : eCAM · 2015Article
- Treatment with aqueous extract from Croton cajucara Benth reduces hepatic oxidative stress in streptozotocin-diabetic rats.Journal of biomedicine & biotechnology · 2012Article
- Sunflower oil supplementation has proinflammatory effects and does not reverse insulin resistance in obesity induced by high-fat diet in C57BL/6 mice.Journal of biomedicine & biotechnology · 2012Article
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5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obesity, type II diabetes, and hyperlipidaemia, which frequently coexist and are strongly associated with oxidative stress, increase the risk of cardiovascular disease. An increase in carbohydrate intake, especially of fructose, and a high-fat diet are both factors that contribute to the development of these metabolic disorders. In recent studies carried out in diabetic rats, authors reported that Ibervillea sonorae had hypoglycaemic activity; saponins and monoglycerides present in the plant could be responsible for the effects observed. In the present study, we determined the effects of an aqueous I. sonorae extract on a murine model of obesity and hyperglycaemia, induced by a high-calorie diet, and the relationship of these effects with hepatic oxidation. A high-fat diet over a period of 8 weeks induced weight gain in the mice and increased triglycerides and blood glucose levels. Simultaneous treatment with I. sonorae aqueous extracts, at doses of 100, 200, and 400 mg/kg, decreased triglycerides and glycaemia levels, prevented an increase in body weight in a dose-dependent manner, and decreased hepatic lipid oxidation at a dose of 200 mg/kg. These data suggest that the aqueous extract from I. sonorae root prevents obesity, dyslipidaemia, and hyperglycaemia induced by a hypercaloric diet; however, high doses may induce toxicity.
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