ArticleWorld journal of gastroenterology2011
C-methacetin breath test reproducibility study reveals persistent CYP1A2 stimulation on repeat examinations.
Article in World journal of gastroenterology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 22 citations in OpenAlex.
- Severe reduction in tacrolimus concentrations with concomitant metamizole (dipyrone) therapy in transplant patients.European journal of clinical pharmacology · 2019Article
- Review
- (13)CO2 breath tests in non-invasive hepatological diagnosis.Przeglad gastroenterologiczny · 2015Review
- Role of the ¹³C-methacetin breath test in the assessment of acute liver injury in a rat model.World journal of gastroenterology · 2014Article
- Phase-1 evaluation of 13C-liver function breath tests.Digestive diseases and sciences · 2013Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo find the most reproducible quantitative parameter of a standard (13)C-methacetin breath test ((13)C-MBT).
methodsTwenty healthy volunteers (10 female, 10 male) underwent the (13)C-MBT after intake of 75 mg (13)C-methacetin p.o. on three occasions. Short- and medium-term reproducibility was assessed with paired examinations taken at an interval of 2 and 18 d (medians), respectively.
resultsThe reproducibility of the 1-h cumulative (13)C recovery (AUC(0-60)), characterized by a coefficient of variation of 10%, appeared to be considerably better than the reproducibility of the maximum momentary (13)C recovery or the time of reaching it. Remarkably, as opposed to the short gap between consecutive examinations, the capacity of the liver to handle (13)C-methacetin increased slightly but statistically significantly when a repeat dose was administered after two to three weeks. Regarding the AUC(0-60), the magnitude of this fixed bias amounted to 7.5%. Neither the time gap between the repeat examinations nor the gender of the subjects affected the (13)C-MBT reproducibility.
conclusion(13)C-MBT is most reproducibly quantified by the cumulative (13)C recovery, but the exactitude thereof may be modestly affected by persistent stimulation of CYP1A2 on repeat examinations.
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