ArticleJournal of immunology (Baltimore, Md. : 1950)2012
The critical role of complement alternative pathway regulator factor H in allergen-induced airway hyperresponsiveness and inflammation.
Article in Journal of immunology (Baltimore, Md. : 1950), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- The Complement-Targeted Inhibitor Mini-FH Protects against Experimental Periodontitis via Both C3-Dependent and C3-Independent Mechanisms.Journal of immunology (Baltimore, Md. : 1950) · 2023Article
- Characterization of Binding Properties of Individual Functional Sites of Human Complement Factor H.Frontiers in immunology · 2020Article
- Effects ofEvidence-based complementary and alternative medicine : eCAM · 2020Article
- The relationship between complement C3 expression and the MUC5B genotype in pulmonary fibrosis.American journal of physiology. Lung cellular and molecular physiology · 2018Article
- Properdin: a tightly regulated critical inflammatory modulator.Immunological reviews · 2016Review
- Properdin-Mediated C5a Production Enhances Stable Binding of Platelets to Granulocytes in Human Whole Blood.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Efficacy of Targeted Complement Inhibition in Experimental C3 Glomerulopathy.Journal of the American Society of Nephrology : JASN · 2016Article
- Complement mediators: key regulators of airway tissue remodeling in asthma.Journal of translational medicine · 2015Review
- Properdin Contributes to Allergic Airway Inflammation through Local C3a Generation.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Complement components as potential therapeutic targets for asthma treatment.Respiratory medicine · 2014Review
- Identification of a novel mode of complement activation on stimulated platelets mediated by properdin and C3(H2O).Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Essential role of surface-bound complement factor H in controlling immune complex-induced arthritis.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Dysregulation of complement system and CD4+ T cell activation pathways implicated in allergic response.PloS one · 2013Article
- Factor h: a complement regulator in health and disease, and a mediator of cellular interactions.Biomolecules · 2012Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Activation of the alternative pathway of complement plays a critical role in the development of allergen-induced airway hyperresponsiveness (AHR) and inflammation in mice. Endogenous factor H, a potent inhibitor of the alternative pathway, is increased in the airways of sensitized and challenged mice, but its role in regulating inflammation or AHR has been unknown. We found that blocking the tissue-binding function of factor H with a competitive antagonist increased complement activation and tissue inflammation after allergen challenge of sensitized mice. Conversely, administration of a fusion protein that contains the iC3b/C3d binding region of complement receptor 2 linked to the inhibitory region of factor H, a molecule directly targeting complement-activating surfaces, protected mice in both primary and secondary challenge models of AHR and lung inflammation. Thus, although endogenous factor H does play a role in limiting the development of AHR, strategies to deliver the complement-regulatory region of factor H specifically to the site of inflammation provide greater protection than that afforded by endogenous regulators. Such an agent may be an effective therapy for the treatment of asthma.
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Registered trials
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