ArticleJournal of applied physiology (Bethesda, Md. : 1985)2012
Brain-specific interleukin-1 receptor accessory protein in sleep regulation.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 37 citations in OpenAlex.
- Alcohol drinking sex-dependently regulates interleukin-1 pro-inflammatory signaling in the prefrontal cortex of mice and rhesus macaques.Brain, behavior, and immunity · 2026Article
- The glymphatic system in sleep: a nexus of waste clearance, brain homeostasis, and disease intervention.Molecular psychiatry · 2026Review
- Smoking disrupts the relationship between cerebrospinal fluid IL-1β and multiple subdimensions of sleep.Brain, behavior, & immunity - health · 2025Article
- Bacterial peptidoglycan levels have brain area, time of day, and sleep loss-induced fluctuations.Frontiers in neuroscience · 2025Article
- Global Deficiency of Alzheimer's Disease Risk GeneASN neuro · 2025Article
- Sleep loss-induced oncogenic pathways are mediated via the neuron-specific interleukin-1 receptor accessory protein (AcPb).Brain, behavior, and immunity · 2025Article
- Cyclooxygenase-2 (COX-2)-dependent mechanisms mediate sleep responses to microbial and thermal stimuli.Brain, behavior, and immunity · 2024Article
- Tripping on the edge of consciousness.Sleep advances : a journal of the Sleep Research Society · 2023Article
- Neuroinflammation, Sleep, and Circadian Rhythms.Frontiers in cellular and infection microbiology · 2022Review
- Role of sleep deprivation in immune-related disease risk and outcomes.Communications biology · 2021Review
- Sleep and circadian rhythms: Evolutionary entanglement and local regulation.Neurobiology of sleep and circadian rhythms · 2020Article
- Sleep- and time of day-linked RNA transcript expression in wild-type and IL1 receptor accessory protein-null mice.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- The relationship between diurnal variation of cytokines and symptom expression in mild obstructive sleep apnea.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2020Observational
- Interleukin-1 receptor accessory proteins are required for normal homeostatic responses to sleep deprivation.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Article
- The neuron-specific interleukin-1 receptor accessory protein alters emergent network state propertiesNeurobiology of sleep and circadian rhythms · 2019Article
- Fatigue, Sleep, and Autoimmune and Related Disorders.Frontiers in immunology · 2019Review
- Interleukin 37 expression in mice alters sleep responses to inflammatory agents and influenza virus infection.Neurobiology of sleep and circadian rhythms · 2017Article
- The NLRP3 inflammasome modulates sleep and NREM sleep delta power induced by spontaneous wakefulness, sleep deprivation and lipopolysaccharide.Brain, behavior, and immunity · 2017Article
- P2X7 receptors in body temperature, locomotor activity, and brain mRNA and lncRNA responses to sleep deprivation.American journal of physiology. Regulatory, integrative and comparative physiology · 2016Article
- Interleukin (IL)-1 in rat parturition: IL-1 receptors 1 and 2 and accessory proteins abundance in pregnant rat uterus at term - regulation by progesterone.Physiological reports · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Interleukin (IL)-1β is involved in several brain functions, including sleep regulation. It promotes non-rapid eye movement (NREM) sleep via the IL-1 type I receptor. IL-1β/IL-1 receptor complex signaling requires adaptor proteins, e.g., the IL-1 receptor brain-specific accessory protein (AcPb). We have cloned and characterized rat AcPb, which shares substantial homologies with mouse AcPb and, compared with AcP, is preferentially expressed in the brain. Furthermore, rat somatosensory cortex AcPb mRNA varied across the day with sleep propensity, increased after sleep deprivation, and was induced by somnogenic doses of IL-1β. Duration of NREM sleep was slightly shorter and duration of REM sleep was slightly longer in AcPb knockout than wild-type mice. In response to lipopolysaccharide, which is used to induce IL-1β, sleep responses were exaggerated in AcPb knockout mice, suggesting that, in normal mice, inflammation-mediated sleep responses are attenuated by AcPb. We conclude that AcPb has a role in sleep responses to inflammatory stimuli and, possibly, in physiological sleep regulation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.