ArticleJournal of applied physiology (Bethesda, Md. : 1985)2012
Heritability of submaximal exercise heart rate response to exercise training is accounted for by nine SNPs.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- DNA Methylation Analysis Identifies Loci for Blood Pressure Regulation.American journal of human genetics · 2017Pooled it
- Physiological and exercise capacity improvements in women completing cardiac rehabilitation.Journal of cardiopulmonary rehabilitation and preventionTrial
- The genetics of human performance.Nature reviews. Genetics · 2022Review
- Relationship between Resting and Recovery Heart Rate in Horses.Animals : an open access journal from MDPI · 2020Article
- Exploring the Activities of RBPMS Proteins in Myocardial Biology.Pediatric cardiology · 2019Review
- Precision exercise medicine: understanding exercise response variability.British journal of sports medicine · 2019Article
- Genetics and the heart rate response to exercise.Cellular and molecular life sciences : CMLS · 2019Review
- Learning one's genetic risk changes physiology independent of actual genetic risk.Nature human behaviour · 2019Article
- Polygenic study of endurance-associated genetic markers ACE I/D, ACTN3 Arg(R)577Ter(X), CKMM A/G NcoI and eNOS Glu(G)298Asp(T) in male Gorkha soldiers.Sports medicine - open · 2017Article
- Skeletal Muscle PGC1α -1 Nucleosome Position and -260 nt DNA Methylation Determine Exercise Response and Prevent Ectopic Lipid Accumulation in Men.Endocrinology · 2017Article
- Endurance Exercise Ability in the Horse: A Trait with Complex Polygenic Determinism.Frontiers in genetics · 2017Article
- TheJournal of sports science & medicine · 2016Article
- Genetic polymorphisms to predict gains in maximal O2 uptake and knee peak torque after a high intensity training program in humans.European journal of applied physiology · 2016Article
- Hypertension and aging.Ageing research reviews · 2016Review
- No Evidence of a Common DNA Variant Profile Specific to World Class Endurance Athletes.PloS one · 2016Article
- The anatomical distribution of genetic associations.Nucleic acids research · 2015Article
- Genetic variation in alpha2-adrenoreceptors and heart rate recovery after exercise.Physiological genomics · 2015Article
- High responders and low responders: factors associated with individual variation in response to standardized training.Sports medicine (Auckland, N.Z.) · 2014Article
- Individual responses to completion of short-term and chronic interval training: a retrospective study.PloS one · 2014Article
- Advances in exercise, fitness, and performance genomics in 2012.Medicine and science in sports and exercise · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
Endurance training-induced changes in hemodynamic traits are heritable. However, few genes associated with heart rate training responses have been identified. The purpose of our study was to perform a genome-wide association study to uncover DNA sequence variants associated with submaximal exercise heart rate training responses in the HERITAGE Family Study. Heart rate was measured during steady-state exercise at 50 W (HR50) on 2 separate days before and after a 20-wk endurance training program in 483 white subjects from 99 families. Illumina HumanCNV370-Quad v3.0 BeadChips were genotyped using the Illumina BeadStation 500GX platform. After quality control procedures, 320,000 single-nucleotide polymorphisms (SNPs) were available for the genome-wide association study analyses, which were performed using the MERLIN software package (single-SNP analyses and conditional heritability tests) and standard regression models (multivariate analyses). The strongest associations for HR50 training response adjusted for age, sex, body mass index, and baseline HR50 were detected with SNPs at the YWHAQ locus on chromosome 2p25 (P = 8.1 × 10(-7)), the RBPMS locus on chromosome 8p12 (P = 3.8 × 10(-6)), and the CREB1 locus on chromosome 2q34 (P = 1.6 × 10(-5)). In addition, 37 other SNPs showed P values <9.9 × 10(-5). After removal of redundant SNPs, the 10 most significant SNPs explained 35.9% of the ΔHR50 variance in a multivariate regression model. Conditional heritability tests showed that nine of these SNPs (all intragenic) accounted for 100% of the ΔHR50 heritability. Our results indicate that SNPs in nine genes related to cardiomyocyte and neuronal functions, as well as cardiac memory formation, fully account for the heritability of the submaximal heart rate training response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.