Evidence map›Paper›PMID 22174319›Full record

ArticleBiological research for nursing2013

Psychoneuroimmunological relationships in women with fibromyalgia.

Victoria Menzies, Debra E Lyon, R K Elswick, Alison J Montpetit, Nancy L McCain

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biological research for nursing, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 44 citations in OpenAlex.

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  13. Depression, evening salivary cortisol and inflammation in chronic fatigue syndrome: A psychoneuroendocrinological structural regression model.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2018
    Article
  14. Article
  15. Article
  16. Article
  17. Depression and pain: testing of serial multiple mediators.Neuropsychiatric disease and treatment · 2016
    Article
  18. Fibromyalgia: A Critical and Comprehensive Review.Clinical reviews in allergy & immunology · 2015
    Review
  19. Article
  20. Is there any association of anxiety-depressive symptoms with vascular endothelial function or systemic inflammation?Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2013
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Victoria MenziesSchool of Nursing and Department of Biostatistics (School of Medicine), Virginia Commonwealth University, Richmond, VA 23298, USA. vsmenzies@vcu.edu
Debra E Lyon
R K Elswick
Alison J Montpetit
Nancy L McCain
Virginia Commonwealth University · US

Funding

Physical Health, Depressive Symptoms, Happiness, and Maternal CompetenceP20NR008988 · NINR · VIRGINIA COMMONWEALTH UNIVERSITY · PI MCCAIN, NANCY L · 2004 to 2008
$1.5M
NINR NIH HHS P20 NR008988NINR NIH HHS P20NR008988
6 · The paper itself

Abstract

introductionThe purpose of this pilot study was to characterize the relationships among perceived stress, pain, fatigue, depression, anxiety, biomarkers, and functional status in women with fibromyalgia syndrome (FMS) using a psychoneuroimmunological (PNI) framework. MATERIALS AND

methodUsing a cross-sectional, correlational design, the authors asked 50 women diagnosed with FMS to complete the Perceived Stress Scale (PSS), Brief Pain Inventory (BPI), Brief Fatigue Inventory (BFI), Center for Epidemiological Studies-Depression scale, State-Trait Anxiety Inventory (STAI), and Functional Impact Questionnaire. The authors analyzed plasma levels of 17 cytokines using a BioPlex® assay and levels of C-reactive protein (CRP) using a high-sensitivity enzyme-linked immunosorbent assay (ELISA).

resultsCompared to published guidelines (>3 mg/L reflects high inflammation), CRP levels were elevated in participating women. Perceived stress demonstrated positive correlations with pain, fatigue, depression, anxiety, and functional status and negative correlations with monocyte chemotactic protein (MCP)-1(r = -.30) and interleukin-1 beta (IL-1β; r = -.29). Pain severity correlated with macrophage inflammatory protein (MIP)-1β (r = .29), and pain interference negatively correlated with IL-1β (r = -.30). Fatigue negatively correlated with IL-1β (r = -.32), interleukin-10 (IL-10; r = -.31), and granulocyte colony-stimulating factor (G-CSF; r = -.31). Depressive symptoms correlated with CRP (r = .31). DISCUSSION: Relationships among perceived stress and symptoms supported the PNI framework. Study findings are similar to previous studies showing that cytokines in persons with FMS do not show a consistent pattern. The elevated CRP levels suggest higher levels of generalized inflammation in the sample and provide evidence for continued development of biobehavioral interventions to address both symptoms and their biological markers over time.

Indexed as

C-Reactive ProteinCross-Sectional StudiesEnzyme-Linked Immunosorbent AssayFemaleFibromyalgiaHumansPain MeasurementStress, PsychologicalC-Reactive Protein

Identifiers

PMID22174319
PMCPMC3722552
OpenAlexW2129034456

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.