Evidence map›Paper›PMID 22174182›Full record

ReviewGenetics2011

Regulation of cell wall biogenesis in Saccharomyces cerevisiae: the cell wall integrity signaling pathway.

David E Levin

Open access · bronzeAbstract readReview
In one paragraph

Review in Genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 450 papers.

0numbers the graph read from it
0cells of the map it votes in
450citing papers in PubMed
17.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

450 citing papers in PubMed, 820 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. HOG Signaling: A Multifunctional Regulator of Stress Homeostasis inJournal of fungi (Basel, Switzerland) · 2026
    Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Response of Psychrotolerant FungusInternational journal of molecular sciences · 2026
    Article
  11. Sus1 Modulates Chromatin Remodeling and Gene Expression via the Cell Wall Integrity Pathway in Saccharomyces cerevisiae.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  12. Article
  13. Article
  14. Genome-wide identification of small GTPase gene family members inApplied and environmental microbiology · 2026
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review

390 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

David E LevinDepartment of Molecular and Cell Biology, Goldman School of Dental Medicine, Boston University, Boston, Massachusetts 02118, USA. delevin@bu.edu
Boston University · US

Funding

ROLE OF PROTEIN KINASE C IN YEAST GROWTH CONTROLR01GM048533 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI LEVIN, DAVID E. · 1992 to 2025
$7.8M
Control of Transcriptional Attenuation of Stress-induced Genes in YeastR01GM102136 · NIGMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI LEVIN, DAVID E. · 2012 to 2015
$1.2M
NIGMS NIH HHS GM48533NIGMS NIH HHS R01 GM048533NIGMS NIH HHS R01 GM102136
6 · The paper itself

Abstract

The yeast cell wall is a strong, but elastic, structure that is essential not only for the maintenance of cell shape and integrity, but also for progression through the cell cycle. During growth and morphogenesis, and in response to environmental challenges, the cell wall is remodeled in a highly regulated and polarized manner, a process that is principally under the control of the cell wall integrity (CWI) signaling pathway. This pathway transmits wall stress signals from the cell surface to the Rho1 GTPase, which mobilizes a physiologic response through a variety of effectors. Activation of CWI signaling regulates the production of various carbohydrate polymers of the cell wall, as well as their polarized delivery to the site of cell wall remodeling. This review article centers on CWI signaling in Saccharomyces cerevisiae through the cell cycle and in response to cell wall stress. The interface of this signaling pathway with other pathways that contribute to the maintenance of cell wall integrity is also discussed.

Indexed as

Signal TransductionCell WallMolecular StructureSaccharomyces cerevisiae

Identifiers

PMID22174182
PMCPMC3241422
OpenAlexW2074743540

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.