ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2012
The microRNA miR-8 is a positive regulator of pigmentation and eclosion in Drosophila.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- MicroRNA-375-3p Targets Fatty Acid Synthase and Relish to Regulate Energy Allocation During Pupal Metamorphosis and Starvation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- The miR-8/miR-200 family: from functional diversification to translational applications.Cellular & molecular biology letters · 2026Review
- microRNAs affecting development of body pigmentation in adult Drosophila melanogaster.bioRxiv : the preprint server for biology · 2026Article
- Polycomb-mediated silencing of miR-8 is required for maintenance of intestinal stemness in Drosophila melanogaster.Nature communications · 2024Article
- miR-252 targeting temperature receptoreLife · 2023Article
- Feeding Asian honeybee queens with European honeybee royal jelly alters body color and expression of related coding and non-coding RNAs.Frontiers in physiology · 2023Article
- MiR-382 Functions on the Regulation of Melanogenesis via Targeting dct in Rainbow Trout (Oncorhynchus mykiss).Marine biotechnology (New York, N.Y.) · 2022Article
- Revisiting the miR-200 Family: A Clan of Five Siblings with Essential Roles in Development and Disease.Biomolecules · 2022Review
- miR-9a regulates levels of both rhomboid mRNA and protein in the early Drosophila melanogaster embryo.G3 (Bethesda, Md.) · 2022Article
- Article
- Drosophila primary microRNA-8 encodes a microRNA-encoded peptide acting in parallel of miR-8.Genome biology · 2021Article
- Identification of shell-color-related microRNAs in the Manila clam Ruditapes philippinarum using high-throughput sequencing of small RNA transcriptomes.Scientific reports · 2021Article
- Insulin signaling mediates neurodegeneration in glioma.Life science alliance · 2021Article
- Post-transcriptional regulation of insect metamorphosis and oogenesis.Cellular and molecular life sciences : CMLS · 2020Review
- MicroRNA-206 Regulation of Skin Pigmentation in Koi Carp (Frontiers in genetics · 2020Article
- The Mantle Exosome and MicroRNAs of Hyriopsis cumingii Involved in Nacre Color Formation.Marine biotechnology (New York, N.Y.) · 2019Article
- Genetic Characteristic and RNA-Seq Analysis in Transparent Mutant of Carp-Goldfish Nucleocytoplasmic Hybrid.Genes · 2019Article
- Integrated analysis of RNA-seq and microRNA-seq depicts miRNA-mRNA networks involved in stripe patterns of Botia superciliaris skin.Functional & integrative genomics · 2019Article
- Co-expression of anti-miR319g and miRStv_11 lead to enhanced steviol glycosides content in Stevia rebaudiana.BMC plant biology · 2019Article
- Systemic signalling and local effectors in developmental stability, body symmetry, and size.Cell stress · 2018Review
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Authors and funding
4 authors.
Funding
Abstract
backgroundMicroRNAs (miRNAs) are short, non-coding RNAs that post-transcriptionally silence gene expression by binding to target mRNAs. Previous studies have identified the miRNA miR-8 as a pleiotropic regulator of Drosophila development, controlling body size and neuronal survival by targeting multiple mRNAs. In this study we demonstrate that miR-8 is also required for proper spatial patterning of pigment on the adult abdominal cuticle in females but not males.
resultsFemale adult flies lacking miR-8 exhibit decreased pigmentation of the dorsal abdomen, with a pattern of pigmentation similar to wild type flies grown at higher temperatures. This pigmentation defect in miR-8 mutants is independent of the previously reported body size defect, and miR-8 acts directly in the developing cuticle to regulate pigmentation patterning. The decrease in pigmentation in miR-8 mutants was more pronounced in flies grown at higher temperatures. We also found that loss of miR-8 dramatically affected the ability to eclose at higher temperatures.
conclusionLoss of miR-8 increased the sensitivity of Drosophila to higher temperatures for both pigmentation patterning and the ability to eclose. Together, these data suggest that miR-8 acts as a buffer to stabilize gene expression patterns in the midst of environmental variation.
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