Evidence map›Paper›PMID 22173953›Full record

Trial reportJournal of neurology2012

Transcranial magnetic stimulation in mild to severe hemiparesis early after stroke: a proof of principle and novel approach to improve motor function.

Adriana B Conforto, Sarah M Anjos, Gustavo Saposnik, Eduardo A Mello, Erina M Nagaya, Waldyr Santos, Karina N Ferreiro, Eduardo S Melo, Felipe I Reis, Milberto Scaff and 1 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of neurology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05657392 (Examination of Changes in Quantitative EEG Parameters Based on Repetitive Transcranial Magnetic Stimulation), which is not on this map. Cited by 44 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05657392 naunknown statusnot on this mapstarted 2021, after this paper: background citation

Examination of Changes in Quantitative EEG Parameters Based on Repetitive Transcranial Magnetic Stimulation (rTMS) Treatment in Patients With Post Stroke

TypeinterventionalSponsorIzmir Katip Celebi UniversityRan2021 to 2024Enrolled50ConditionsStroke, Stroke, Ischemic, Stroke/Brain AttackArmsrepetitive Transcranial Magnetic Stimulation (rTMS), 32 electrode electroencephalography (EEG)
3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 9 syntheses or guidelines pooled it.

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  4. Efficacy of rTMS in treating functional impairment in post-stroke patients: a systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
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  17. Clinical application of repetitive transcranial magnetic stimulation in improving functional impairments post-stroke: review of the current evidence and potential challenges.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Adriana B ConfortoUniversity of São Paulo, São Paulo, Brazil. adriana.conforto@gmail.com
Sarah M Anjos
Gustavo Saposnik
Eduardo A Mello
Erina M Nagaya
Waldyr Santos
Karina N Ferreiro
Eduardo S Melo
Felipe I Reis
Milberto Scaff
Leonardo G Cohen

Funding

Cortical reorganization and plasticity In the Healthy BrainZIANS002978 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI COHEN, LEONARDO GREGORIO · 2009 to 2025
$38.0M
Modulating brain plasticity in rehabilitation of stroke and other brain lesionsZIANS003030 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI COHEN, LEONARDO GREGORIO · 2009 to 2025
$23.2M
Intramural NIH HHS ZIA NS002978
6 · The paper itself

Abstract

Low-frequency repetitive transcranial magnetic stimulation (rTMS) of the unaffected hemisphere can enhance function of the paretic hand in patients with mild motor impairment. Effects of low-frequency rTMS to the contralesional motor cortex at an early stage of mild to severe hemiparesis after stroke are unknown. In this pilot, randomized, double-blind clinical trial we compared the effects of low-frequency rTMS or sham rTMS as add-on therapies to outpatient customary rehabilitation, in 30 patients within 5-45 days after ischemic stroke, and mild to severe hand paresis. The primary feasibility outcome was compliance with the interventions. The primary safety outcome was the proportion of intervention-related adverse events. Performance of the paretic hand in the Jebsen-Taylor test and pinch strength were secondary outcomes. Outcomes were assessed at baseline, after ten sessions of treatment administered over 2 weeks and at 1 month after end of treatment. Baseline clinical features were comparable across groups. For the primary feasibility outcome, compliance with treatment was 100% in the active group and 94% in the sham group. There were no serious intervention-related adverse events. There were significant improvements in performance in the Jebsen-Taylor test (mean, 12.3% 1 month after treatment) and pinch force (mean, 0.5 Newtons) in the active group, but not in the sham group. Low-frequency rTMS to the contralesional motor cortex early after stroke is feasible, safe and potentially effective to improve function of the paretic hand, in patients with mild to severe hemiparesis. These promising results will be valuable to design larger randomized clinical trials.

Indexed as

AdolescentAdultAgedAged, 80 and overDouble-Blind MethodFemaleFunctional LateralityHumansMaleMiddle AgedMotor CortexMovementParesisPilot ProjectsStrokeTranscranial Magnetic Stimulation

Identifiers

PMID22173953
PMCPMC4883097

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.