Evidence map›Paper›PMID 22173948›Full record

ArticleInfection2012

Long-term immunogenicity of hepatitis B vaccination in children and adolescents in a southern Italian town.

T Stroffolini, V Guadagnino, B Caroleo, G De Sarro, A Focà, M C Liberto, A Giancotti, G S Barreca, N Marascio, F L Lombardo and 2 more

Abstract read
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In one paragraph

Article in Infection, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact, top 88% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

T StroffoliniDepartment of Infectious and Tropical Diseases, Institute of Tropical Diseases, Policlinico Umberto I, Viale del Policlinico 155, 00161, Rome, Italy. t.stroffolini@policlinicoumberto1.it
V Guadagnino
B Caroleo
G De Sarro
A Focà
M C Liberto
A Giancotti
G S Barreca
N Marascio
F L Lombardo
O Staltari
“Sersale’s Study” Group
Magna Graecia University · ITIstituto Superiore di Sanità · ITPoliclinico Umberto I · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeUniversal anti-hepatitis B vaccination of infants and of 12-year-old children became mandatory in Italy in 1991. The purpose of this study was to evaluate the persistence of anti-hepatitis B surface (HBs) antibodies several years after a primary course of vaccination.

methodsIn 2010, anti-HBs titers were measured in all subjects aged between 5 and 25 years residing in a southern Italian town. Individuals with an anti-hepatitis B antibody concentration of 10 IU/ml or more were considered to be protected.

resultsOf the 671 subjects evaluated, 149 (30%) lacked protective antibodies. Fifty-three (29.4%) of the subjects had been vaccinated ≤10 years earlier and 96 (30.3%) more than 10 years earlier (P = not significant). Subjects vaccinated in infancy were more likely to lack protective anti-HBs antibodies than subjects vaccinated at 12 years of age, regardless of the years elapsed since immunization.

conclusionsMost subjects maintained protective antibodies for a considerable number of years after vaccination. Vaccination in adolescence results in more prolonged immunogenicity than vaccination in infancy.

Indexed as

AdolescentAdultChildChild, PreschoolEnzyme-Linked Immunosorbent AssayFemaleHepatitis BHepatitis B AntibodiesHepatitis B Core AntigensHepatitis B Surface AntigensHepatitis B VaccinesHepatitis B virusHumansItalyMaleTime FactorsHepatitis B AntibodiesHepatitis B Core AntigensHepatitis B Surface AntigensHepatitis B Vaccines

Identifiers

PMID22173948
OpenAlexW2041987173

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.