ArticleAJNR. American journal of neuroradiology2012
Longitudinal magnetization transfer imaging in mild to severe Alzheimer disease.
Article in AJNR. American journal of neuroradiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 23 citations in OpenAlex.
- Quantitative magnetic resonance imaging in Alzheimer's disease: a narrative review.Quantitative imaging in medicine and surgery · 2025Review
- Pattern of Altered Magnetization Transfer Rate in Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2022Article
- Saturation Transfer MRI for Detection of Metabolic and Microstructural Impairments Underlying Neurodegeneration in Alzheimer's Disease.Brain sciences · 2021Review
- Neuroprotective Studies of Evodiamine in an Okadaic Acid-Induced Neurotoxicity.International journal of molecular sciences · 2021Article
- Application value of serum biomarkers for choosing memantine therapy for moderate AD.Journal of neurology · 2018Article
- TMagnetic resonance imaging · 2018Article
- Associations between brain white matter integrity and disease severity in obstructive sleep apnea.Journal of neuroscience research · 2016Article
- Low MT ratio in hippocampus of amnestic MCI patients who will progress to AD.Journal of neurology · 2016Article
- Association between changes in brain microstructure and cognition in older subjects at increased risk for vascular disease.BMC neurology · 2015Article
- Quantitative multi-modal MRI of the Hippocampus and cognitive ability in community-dwelling older subjects.Cortex; a journal devoted to the study of the nervous system and behavior · 2014Article
- Magnetization transfer ratio relates to cognitive impairment in normal elderly.Frontiers in aging neuroscience · 2014Article
- Classification of mild cognitive impairment and Alzheimer disease using model-based MR and magnetization transfer imaging.AJNR. American journal of neuroradiology · 2013Article
- Brain imaging of mild cognitive impairment and Alzheimer's disease.Neural regeneration research · 2013Article
- Multimodality Imaging Approach in Alzheimer disease. Part I: Structural MRI, Functional MRI, Diffusion Tensor Imaging and Magnetization Transfer Imaging.Dementia & neuropsychologiaReview
- Magnetization transfer contrast imaging detects early white matter changes in the APP/PS1 amyloidosis mouse model.NeuroImage. ClinicalArticle
- Regional analysis of the magnetization transfer ratio of the brain in mild Alzheimer disease and amnestic mild cognitive impairment.AJNR. American journal of neuroradiologyArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeMTI has been proposed as a sensitive technique for studying microstructural brain tissue changes in patients with AD, but the course of these changes over time is largely unknown. We therefore used a placebo-controlled study of memantine to follow the evolution of tissue damage in AD by means of MTR measurements and investigated how MTR changes were related to brain atrophy and cognition. MATERIALS AND
methodsTwenty-eight patients (76.5 ± 5.8 years) with mild to moderate AD underwent MTI, brain volume measurements, and cognitive testing at baseline and after 6 and 12 months. Nineteen healthy individuals (73.3 ± 3.2 years) served as controls. MTI was performed with a 2-minute protocol that was optimized for an enhanced MT effect and reduced motion sensitivity. Global and regional MTR measurements served as correlations with brain volumes and the MMSE score.
resultsAD patients had significantly lower global MTR values than controls, and showed a consistent and significant MTR reduction in all regions investigated over a period of 12 months. These MTR changes were paralleled by a brain tissue loss of 2.2% per year. Associations between MTR and cognition were found for the hippocampus, putamen, and thalamus, and were more pronounced in the left hemisphere.
conclusionsMTI in AD allows the assessment of ongoing global and regional brain damage independent of atrophy, and therefore appears to be a valuable marker for disease-related tissue changes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.