ArticleAJNR. American journal of neuroradiology2012
Distinguishing between germinomas and pineal cell tumors on MR imaging.
Article in AJNR. American journal of neuroradiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 109 citations in OpenAlex.
- Quantification of heterogeneity as a biomarker in tumor imaging: a systematic review.PloS one · 2014Pooled it
- Pilocytic astrocytoma surgery via the pineal region in a 9-year-old boy via the infratentorial-supracerebellar approach.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Article
- How is rosette formation in brain tumours linked with cerebrospinal fluid spread?Brain tumor pathology · 2026Review
- Neurosurgical management of pineal lesions: Insights from a single-center study of 27 cases.BioMedicine · 2026Article
- Imaging of Pineal Region Masses.Advances and technical standards in neurosurgery · 2026Review
- Pineal Gland Parenchyma Tumors.Advances and technical standards in neurosurgery · 2026Review
- Pathology of the conus medullaris and cauda equina. Beyond the usual suspects.Insights into imaging · 2025Article
- Pineal region tumors: prognostic stratification based on magnetic resonance imaging features-a retrospective cohort study.Quantitative imaging in medicine and surgery · 2025Article
- An aggressive, unresected pineoblastoma in an adult woman: the role of exclusive radiotherapy - a case report and literature review.Ecancermedicalscience · 2025Article
- Plasma miRNA expression profile in pediatric pineal pure germinomas.Frontiers in oncology · 2024Article
- Benign and Malignant Tumors of the Pineal Region.Advances in experimental medicine and biology · 2023Article
- Restricted diffusion in benign intracranial neoplasms: a narrative review.Polish journal of radiology · 2023Review
- Article
- Mixed germ cell tumor of the pineal gland in a pediatric patient.Radiology case reports · 2022Article
- MR Imaging of Pediatric Brain Tumors.Diagnostics (Basel, Switzerland) · 2022Review
- Supratentorial Pediatric Midline Tumors and Tumor-like Lesions: Clinical Spectrum, Natural History and Treatment Options.Children (Basel, Switzerland) · 2022Review
- Neuroimaging of paediatric pineal, sellar and suprasellar tumours: a guide to differential diagnosis.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2022Review
- Mission impossible: chemotherapy in the intensive care for pineal region germ cell tumor.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2022Article
- Pineal Gland Tumors: A Review.Cancers · 2021Review
- Mixed germ cell tumor infiltrating the pineal gland without elevated tumor markers: illustrative case.Journal of neurosurgery. Case lessons · 2021Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeTumors of pineal cell origin have different prognosis and treatment than those of germ cell origin. The recent literature suggests that these tumors often look alike. Our study aimed to differentiate between pineal cell tumor and germinoma based on ADC values, the homogeneity of the mass, and MR imaging characteristics. MATERIALS AND
methodsWe enrolled 20 patients who had pretreatment MR imaging scans with histologic verification of tumors of pineal cell origin and germinomas. The tumors were measured for the ADC values and for homogeneity by the coefficient of variation of ADC values, and T1WI and T2WI signal intensity values.
resultsThe 20 subjects (8 females and 12 males) ranged in age from 1.5-64.9 years, with a mean age of 23.9 years (SD 17.7 years). The mean age of those with germinomas was 13.7 years (SD 3.8 years), less than the mean of 29.4 years for those with pineal cell tumors (SD 19.9 years; P = .016). These 2 groups showed no significant difference in coefficients of variation on T1WI, T2WI, and ADC images. However, germinomas showed statistically significant higher ADC values (mean 1590.69 ± 532.96 × 10(-6) mm(2)/s) than pineal cell tumors (mean 883.58 ± 317.48 × 10(-6) mm(2)/s; P = .02). An accuracy of 89.5%, sensitivity of 83.3%, specificity of 92.3%, PPV of 83.3%, and NPV of 92.3% were yielded for an ADC threshold of 1250.00 × 10(-6) mm(2)/s.
conclusionsGerminomas showed higher ADC values than the pineal cell tumors (P = .02), and the patients were younger. Otherwise, there were no definitive imaging characteristics that distinguished pineal cell tumors from germinomas.
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