ArticleMolecular biology reports2012
PTGS2 (COX2) -765G>C gene polymorphism and risk of sporadic colorectal cancer in Iranian population.
Article in Molecular biology reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 5 of them syntheses that pooled it.
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15 citing papers in PubMed, 5 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- Systematic review: interactions between aspirin, and other nonsteroidal anti-inflammatory drugs, and polymorphisms in relation to colorectal cancer.Alimentary pharmacology & therapeutics · 2014Pooled it
- Meta-analysis of the association between COX-2 polymorphisms and risk of colorectal cancer based on case-control studies.PloS one · 2014Pooled it
- Cyclooxygenase-2 polymorphisms and susceptibility to colorectal cancer: a meta-analysis.Yonsei medical journal · 2013Pooled it
- A meta-analysis of PTGS1 and PTGS2 polymorphisms and NSAID intake on the risk of developing cancer.PloS one · 2013Pooled it
- Pooled it
- Article
- Genetic polymorphisms of pharmacogenomic VIP variants in the Dai population from Yunnan province.Molecular genetics & genomic medicine · 2020Article
- Single Nucleotide Variants Associated with Colorectal Cancer Among Iranian Patients: A Narrative Review.Pharmacogenomics and personalized medicine · 2020Review
- Single nucleotide polymorphism rs4648298 in miRNAs hsa-miR21 and hsa-miR590 binding site ofJournal of gastrointestinal oncology · 2018Article
- Association ofIranian journal of public health · 2016Article
- Early detection of colorectal cancer: from conventional methods to novel biomarkers.Journal of cancer research and clinical oncology · 2016Review
- Methylation pattern of ALX4 gene promoter as a potential biomarker for blood-based early detection of colorectal cancer.Advanced biomedical research · 2015Article
- Methylation pattern of SFRP1 promoter in stool sample is a potential marker for early detection of colorectal cancer.Advanced biomedical research · 2012Article
- DNA methylation analysis of secreted frizzled-related protein 2 gene for the early detection of colorectal cancer in fecal DNA.Nigerian medical journal : journal of the Nigeria Medical AssociationArticle
- POLYMORPHISM OF THE COX-2 GENE AND SUSCEPTIBILITY TO COLON AND RECTAL CANCER.Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgeryArticle
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3 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Colorectal cancer (CRC) is one of the leading cancers worldwide. Through genome wide association studies, several single nucleotide polymorphisms scattered in the genome emerged to be influential in the development of sporadic CRC in some populations. However, replicative studies failed to prove a particular SNP-CRC association in populations and ethnic groups. Cyclooxygenase-2 (PTGS2) is a crucial enzyme involved in the metabolism of prostaglandins. The aim of this replicative study is to investigate the possible association between PTGS2 -765G>C polymorphism and sporadic CRC risk in a subset of Iranian population. A total of 110 patients with sporadic CRC, and 120 controls were genotyped for PTGS2 -765G>C polymorphism by using polymerase chain reaction-based restriction fragment length polymorphism. There were no significant differences in the genotype and allele frequencies of PTGS2 -765G>C between two groups except in irregular aspirin or non-steroidal anti-inflammatory drugs (NSAID) consumers. Frequencies of genotypes and alleles were as follows: GG = 44.2, GC = 48.3, CC = 7.5%, in controls and GG = 34.55, GC = 60.9, CC = 4.55% in cases. Regarding the allele frequency, the following values were found: G = 65, C = 35% in cases and 68.3, 31.7% in the controls, respectively. In irregular aspirin or NSAID consumers combined GC+CC genotype was found to be a risk genotype (OR = 1.933, 95% CI: 1.067-3.501, P = 0.036). Overall, no significant relation was found between this polymorphism and sporadic CRC in Iranians. However, in irregular aspirin or NSAID consumers the combined GC+CC genotype proved to be a risk genotype.
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