ArticleInfection control and hospital epidemiology2012
Frequent hospital readmissions for Clostridium difficile infection and the impact on estimates of hospital-associated C. difficile burden.
Article in Infection control and hospital epidemiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Incidence and Outcomes Associated With Clostridium difficile Infections: A Systematic Review and Meta-analysis.JAMA network open · 2020Pooled it
- Global burden ofJournal of global health · 2019Pooled it
- The economic impact of Clostridium difficile infection: a systematic review.The American journal of gastroenterology · 2015Pooled it
- Measuring the Direct Medical Costs of Hospital-Onset Infections Using an Analogy Costing Framework.PharmacoEconomics · 2024Article
- Article
- Effect of clinical versus administrative data definitions on the epidemiology of C. difficile among hospitalized individuals with IBD: a population-based cohort study.BMC gastroenterology · 2022Article
- Treatment of Helicobacter pylori Is Not Associated With Future Clostridium difficile Infection.The American journal of gastroenterology · 2020Article
- Community-OnsetOpen forum infectious diseases · 2019Article
- Bezlotoxumab Is Associated With a Reduction in Cumulative Inpatient-Days: Analysis of the Hospitalization Data From the MODIFY I and II Clinical Trials.Open forum infectious diseases · 2018Article
- Retrospective analysis of long-term gastrointestinal symptoms after Clostridium difficile infection in a nonelderly cohort.PloS one · 2018Article
- Incidence and Outbreak of Healthcare-Onset Healthcare-AssociatedFrontiers in microbiology · 2018Article
- Article
- Clostridium difficile infection health disparities by race among hospitalized adults in the United States, 2001 to 2010.BMC infectious diseases · 2016Article
- The impact of the introduction of fidaxomicin on the management of Clostridium difficile infection in seven NHS secondary care hospitals in England: a series of local service evaluations.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2016Article
- Impact of Hospital Population Case-Mix, Including Poverty, on Hospital All-Cause and Infection-Related 30-Day Readmission Rates.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2015Article
- Racial Differences in Clostridium difficile Infection Rates Are Attributable to Disparities in Health Care Access.Antimicrobial agents and chemotherapy · 2015Article
- The Likelihood of Hospital Readmission Among Patients With Hospital-Onset Central Line-Associated Bloodstream Infections.Infection control and hospital epidemiology · 2015Article
- Disproportionate rise in Clostridium difficile-associated hospitalizations among US youth with inflammatory bowel disease, 1997-2011.Journal of pediatric gastroenterology and nutrition · 2015Article
- Understanding the current state of infection prevention to prevent Clostridium difficile infection: a human factors and systems engineering approach.American journal of infection control · 2015Article
- Initiation of sporulation in Clostridium difficile: a twist on the classic model.FEMS microbiology letters · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
objectiveClostridium difficile infection (CDI) is associated with hospitalization and may cause readmission following admission for any reason. We aimed to measure the incidence of readmissions due to CDI.
designRetrospective cohort study. PATIENTS: Adult inpatients in Orange County, California, who presented with new-onset CDI within 12 weeks of discharge.
methodsWe assessed mandatory 2000-2007 hospital discharge data for trends in hospital-associated CDI (HA-CDI) incidence, with and without inclusion of postdischarge CDI (PD-CDI) events resulting in rehospitalization within 12 weeks of discharge. We measured the effect of including PD-CDI events on hospital-specific CDI incidence, a mandatory reporting measure in California, and on relative hospital ranks by CDI incidence.
resultsFrom 2000 to 2007, countywide hospital-onset CDI (HO-CDI) incidence increased from 15 per 10,000 to 22 per 10,000 admissions. When including PD-CDI events, HA-CDI incidence doubled (29 per 10,000 in 2000 and 52 per 10,000 in 2007). Overall, including PD-CDI events resulted in significantly higher hospital-specific CDI incidence, although hospitals had disproportionate amounts of HA-CDI occurring postdischarge. This resulted in substantial shifts in some hospitals' rankings by CDI incidence. In multivariate models, both HO and PD-CDI were associated with increasing age, higher length of stay, and select comorbidities. Race and Hispanic ethnicity were predictive of PD-CDI but not HO-CDI.
conclusionsPD-CDI events associated with rehospitalization are increasingly common. The majority of HA-CDI cases may be occurring postdischarge, raising important questions about both accurate reporting and effective prevention strategies. Some risk factors for PD-CDI may be different than those for HO-CDI, allowing additional identification of high-risk groups before discharge.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.