ArticleJournal of hepatology2012
Quantitative dynamics of hepatitis B basal core promoter and precore mutants before and after HBeAg seroconversion.
Article in Journal of hepatology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Near extinction of the HBV quasispecies driven by the hard selective sweep in chronic hepatitis B.mBio · 2025Article
- A cautionary note to hepatitis B e antigen (HBeAg)-negative test results in pregnant women in an area prevalent of HBeAg-negative chronic hepatitis B.Journal of medical virology · 2023Article
- Acute and chronic HBV infection in central Argentina: High frequency of sub-genotype F1b, low detection of clinically relevant mutations and first evidence of HDV.Frontiers in medicine · 2022Article
- The evolution and clinical impact of hepatitis B virus genome diversity.Nature reviews. Gastroenterology & hepatology · 2020Review
- Conservative Evolution of Hepatitis B Virus Precore and Core Gene During Immune Tolerant Phase in Intrafamilial Transmission.Virologica Sinica · 2020Article
- Article
- New and Old Biomarkers for Diagnosis and Management of Chronic Hepatitis B Virus Infection.Gastroenterology · 2019Review
- Article
- Elimination of Hepatitis B: Is It a Mission Possible?BMC medicine · 2017Review
- Mutation Changes in the preC/Core Promoter in HBeAg-Positive Patients With Chronic Hepatitis B During Interferon Therapy.Medicine · 2016Observational
- Hepatitis B Virus Core Promoter Double Mutations (A1762T, G1764A) Are Associated with Lower Levels of Serum Dihydrolipoyl Dehydrogenase.Intervirology · 2016Article
- The incidence rate over 10 years of naturally occurring, cancer related mutations in the basal core promoter of hepatitis B virus.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2015Article
- Precore/basal core promoter mutants quantification throughout phases of hepatitis B virus infection by Simpleprobe.World journal of gastroenterology · 2015Article
- Lower mutation frequency of BCP/precore regions in e antigen-negative chronic HBV-infected children instead of adults patients.PloS one · 2015Article
- New perspective on the natural course of chronic HBV infection.Frontiers of medicine · 2014Review
- Core promoter: a critical region where the hepatitis B virus makes decisions.World journal of gastroenterology · 2014Review
- Frequency-dependent selection drives HBeAg seroconversion in chronic hepatitis B virus infection.Evolution, medicine, and public health · 2014Article
- Quasispecies structure, cornerstone of hepatitis B virus infection: mass sequencing approach.World journal of gastroenterology · 2013Review
- HBsAg, HBeAg and HBV DNA level changes and precore/basal core promoter mutations in the natural history of chronic hepatitis B in Indonesian patients.Hepatology international · 2013Article
- SASLT practice guidelines for the management of Hepatitis B virus - An update.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology AssociationArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
BACKGROUND &
aimsHepatitis B e antigen (HBeAg) seroconversion is an important clinical and virological "landmark" during chronic hepatitis B virus (HBV) infection. Mutant viruses carrying the precore G1896A and/or the basal core promoter (BCP) A1762T/G1764A mutations are associated with HBeAg seroconversion. However, the exact role of these mutants in HBeAg seroconversion remains unclear, partly because the evolution of these mutant viruses before and after seroconversion has not been well studied.
methodsUsing our novel mutant quantification methods, the percentage of the mutant viruses was analyzed both cross-sectionally and longitudinally, before and after seroconversion.
resultsCross-sectional analysis showed that the percentage of both precore and BCP mutants gradually increased with age in the HBeAg-positive population. Follow-up of 18 HBeAg-positive patients revealed that the mutant percentage may stay low and stable for many years, followed by a steady increase in the percentage of G1896A and/or A1762T/G1764A mutants, from <10% to 50-100%, within about 3 years prior to seroconversion. In all cases, increase of mutant percentage was preceded or accompanied by elevated serum alanine aminotransferase. After the seroconversion, the mutant percentage could remain high or decrease significantly, sometimes to below 20%.
conclusionsLevels of G1896A and A1762T/G1764A mutants (of genotypes B and C) in the HBeAg-positive patients may predict the time of HBeAg seroconversion. The dominance of these mutants in the HBeAg-positive phase is more likely the result of immune selection rather than the enhanced replication capability of the mutants. However, anti-HBe antibody may not be a major selection force for these mutants.
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Registered trials
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