ReviewThe American journal of the medical sciences2012
Alcohol abuse, the alveolar macrophage and pneumonia.
Review in The American journal of the medical sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 3 syntheses or guidelines pooled it, 73 citations in OpenAlex.
- Pneumococcal Vaccine for Adults Aged ≥19 Years: Recommendations of the Advisory Committee on Immunization Practices, United States, 2023.MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports · 2023Guideline
- Pooled it
- The relationship between different dimensions of alcohol use and the burden of disease-an update.Addiction (Abingdon, England) · 2017Pooled it
- Alcohol-induced altered glycans in human tracheal epithelial cells promote bacterial adhesion.FEBS open bio · 2026Article
- Ethanol-induced Nrf2 suppression in the lung is mediated by AP-1-driven expression of miR-144.Alcohol, clinical & experimental research · 2025Article
- Pioglitazone reverses alcohol-induced alterations in alveolar macrophage mitochondrial phenotype.Alcohol, clinical & experimental research · 2024Article
- Phenobarbital versus benzodiazepines in alcohol withdrawal syndrome.Neuropsychopharmacology reports · 2023Article
- Global burden of influenza lower respiratory tract infections in older people from 1990 to 2019.Aging clinical and experimental research · 2023Article
- Review
- The association between early onset of alcohol, smokeless tobacco and marijuana use with adult binge drinking in United States.Scientific reports · 2023Article
- Chronic alcohol administration alters metabolomic profile of murine bone marrow.Frontiers in immunology · 2023Article
- Age-sex differences in the global burden of lower respiratory infections and risk factors, 1990-2019: results from the Global Burden of Disease Study 2019.The Lancet. Infectious diseases · 2022Article
- Alcohol use disorder and liver injury related to the COVID-19 pandemic.World journal of hepatology · 2022Review
- Prenatal and adolescent alcohol exposure programs immunity across the lifespan: CNS-mediated regulation.Pharmacology, biochemistry, and behavior · 2022Review
- The Impact of Alcohol Use Disorder on Tuberculosis: A Review of the Epidemiology and Potential Immunologic Mechanisms.Frontiers in immunology · 2022Review
- Alcohol-Induced Glycolytic Shift in Alveolar Macrophages Is Mediated by Hypoxia-Inducible Factor-1 Alpha.Frontiers in immunology · 2022Article
- Combination of s-methyl cysteine and protocatechuic acid provided greater lipid-lowering and anti-inflammatory effects in mice liver against chronic alcohol consumption.Iranian journal of basic medical sciences · 2021Article
- Alcohol induces mitochondrial derangements in alveolar macrophages by upregulating NADPH oxidase 4.Alcohol (Fayetteville, N.Y.) · 2021Article
- Alcohol use disorder: A pre-existing condition for COVID-19?Alcohol (Fayetteville, N.Y.) · 2021Review
- Retrospective study on rib fractures: smoking and alcohol matter for mortality and complications.Trauma surgery & acute care open · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Alcohol use, and misuse, has been a part of human culture for thousands of years. In the modern medical era, a great deal of attention has been justifiably focused on elucidating the mechanisms underlying the psychological and biological addiction to alcohol. However, a significant percentage, if not the majority, of alcohol-related morbidity and mortality occurs in individuals who do not meet the formal diagnostic criteria for alcohol use disorders. For example, many serious medical consequences of chronic alcohol ingestion can occur in individuals who do not have signs or symptoms of alcohol dependence. There is now clear evidence that even in otherwise healthy-appearing individuals who chronically consume excessive amounts of alcohol, alveolar macrophage immune capacity is impaired and, as a consequence, these individuals are at significantly increased risk of pneumonia. This brief review summarizes some of the key mechanisms underlying this phenomenon and proposes a hypothetical scheme by which alcohol interferes with zinc bioavailability within the alveolar space and thereby dampens macrophage function.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.