Evidence map›Paper›PMID 22172994›Full record

ReviewBiochimica et biophysica acta

Mitochondrial poly(A) polymerase and polyadenylation.

Jeong Ho Chang, Liang Tong

Abstract readReview
In one paragraph

Review in Biochimica et biophysica acta. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 99 citations in OpenAlex.

  1. Article
  2. ReducedbioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Mitogenome of Endemic Species of Flying Squirrel,Animals : an open access journal from MDPI · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Translation in Mitochondrial Ribosomes.Methods in molecular biology (Clifton, N.J.) · 2023
    Article
  17. Review
  18. Article
  19. Article
  20. Evolution of mitochondrial RNA editing in extant gymnosperms.The Plant journal : for cell and molecular biology · 2022
    Article

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Jeong Ho ChangDepartment of Biological Sciences, Columbia University, New York, NY 10027, USA.
Liang Tong
Columbia University · US

Funding

Structural biology of pre-mRNA 3'-end processingR01GM077175 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI TONG, LIANG · 2007 to 2015
$2.8M
NIGMS NIH HHS GM077175NIGMS NIH HHS R01 GM077175
6 · The paper itself

Abstract

Polyadenylation of mitochondrial RNAs in higher eukaryotic organisms have diverse effects on their function and metabolism. Polyadenylation completes the UAA stop codon of a majority of mitochondrial mRNAs in mammals, regulates the translation of the mRNAs, and has diverse effects on their stability. In contrast, polyadenylation of most mitochondrial mRNAs in plants leads to their degradation, consistent with the bacterial origin of this organelle. PAPD1 (mtPAP, TUTase1), a noncanonical poly(A) polymerase (ncPAP), is responsible for producing the poly(A) tails in mammalian mitochondria. The crystal structure of human PAPD1 was reported recently, offering molecular insights into its catalysis. This article is part of a Special Issue entitled: Mitochondrial Gene Expression.

Indexed as

DNA-Directed RNA PolymerasesMitochondriaMitochondrial ProteinsRNA, MessengerAnimalsHumansPlantsPolyadenylationProtein ConformationRNA, MitochondrialRNA StabilityYeastsDNA-Directed RNA Polymerasesmitochondrial messenger RNAMitochondrial ProteinsMTPAP protein, humanRNA, MessengerRNA, Mitochondrial

Identifiers

PMID22172994
PMCPMC3307840
OpenAlexW1979537172

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.