ReviewBiochimica et biophysica acta2012
Gating and regulation of the cytochrome c oxidase proton pump.
Review in Biochimica et biophysica acta, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 76 citations in OpenAlex.
- Interaction of Terminal Oxidases with Amphipathic Molecules.International journal of molecular sciences · 2023Review
- Structural basis of mammalian complex IV inhibition by steroids.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Direct Interaction of Mitochondrial CytochromeCells · 2022Article
- Structure and Mechanism of Respiratory III-IV Supercomplexes in Bioenergetic Membranes.Chemical reviews · 2021Review
- The complete mitogenome ofEcology and evolution · 2021Article
- Article
- Thermodynamic efficiency, reversibility, and degree of coupling in energy conservation by the mitochondrial respiratory chain.Communications biology · 2020Article
- Evidence for Adaptive Selection in the Mitogenome of a Mesoparasitic Monogenean FlatwormGenes · 2019Article
- Mitochondrial OXPHOS genes provides insights into genetics basis of hypoxia adaptation in anchialine cave shrimps.Genes & genomics · 2018Article
- Comparison of redox and ligand binding behaviour of yeast and bovine cytochrome c oxidases using FTIR spectroscopy.Biochimica et biophysica acta. Bioenergetics · 2018Article
- Control of transmembrane charge transfer in cytochrome c oxidase by the membrane potential.Nature communications · 2018Article
- The electron distribution in the "activated" state of cytochrome c oxidase.Scientific reports · 2018Article
- Organ reserve, excess metabolic capacity, and aging.Biogerontology · 2018Review
- Augmented mitochondrial cytochrome c oxidase activity in children with iron deficiency: a tandem between iron and copper?Archives of medical science : AMS · 2018Article
- Cox2A/Cox2B subunit interaction in Polytomella sp. cytochrome c oxidase: role of the Cox2B subunit extension.Journal of bioenergetics and biomembranes · 2017Article
- Role of conformational change and K-path ligands in controlling cytochromeBiochemical Society transactions · 2017Review
- Splitting of the O-O bond at the heme-copper catalytic site of respiratory oxidases.Science advances · 2017Article
- It is rocket science - why dietary nitrate is hard to 'beet'! Part II: further mechanisms and therapeutic potential of the nitrate-nitrite-NO pathway.British journal of clinical pharmacology · 2017Article
- Rapid Electron Transfer within the III-IV Supercomplex in Corynebacterium glutamicum.Scientific reports · 2016Article
- Regulatory role of the respiratory supercomplex factors in Saccharomyces cerevisiae.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
As a consumer of 95% of the oxygen we breathe, cytochrome c oxidase plays a major role in the energy balance of the cell. Regulation of its oxygen reduction and proton pumping activity is therefore critical to physiological function in health and disease. The location and structure of pathways for protons that are required to support cytochrome c oxidase activity are still under debate, with respect to their requirements for key residues and fixed waters, and how they are gated to prevent (or allow) proton backflow. Recent high resolution structures of bacterial and mammalian forms reveal conserved lipid and steroid binding sites as well as redox-linked conformational changes that provide new insights into potential regulatory ligands and gating modes. Mechanistic interpretation of these findings and their significance for understanding energy regulation is discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.