ArticleJournal of lipid research2012
LYCAT, a homologue of C. elegans acl-8, acl-9, and acl-10, determines the fatty acid composition of phosphatidylinositol in mice.
Article in Journal of lipid research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 64 citations in OpenAlex.
- An evolutionary analysis of lysophospholipid acyltransferases generating membrane phospholipid diversity.Frontiers in immunology · 2026Article
- Transcriptomic Analysis Reveals Regulatory Responses of Fatty Acid Positional Distribution in Triacylglycerols and Lipid Composition to Dietary n-3 HUFA in the Muscle ofAnimals : an open access journal from MDPI · 2025Article
- The LCLAT1/LYCAT acyltransferase is required for EGF-mediated phosphatidylinositol-3,4,5-trisphosphate generation and Akt signaling.Molecular biology of the cell · 2024Article
- The critical role of cardiolipin in metazoan differentiation, development, and maturation.Developmental dynamics : an official publication of the American Association of Anatomists · 2023Review
- Identification and characterization of LPLAT7 as an sn-1-specific lysophospholipid acyltransferase.Journal of lipid research · 2022Article
- Cancer stem cells induced by chronic stimulation with prostaglandin E2 exhibited constitutively activated PI3K axis.Scientific reports · 2022Article
- Metabolic routing maintains the unique fatty acid composition of phosphoinositides.EMBO reports · 2022Article
- Review
- Porcine liver decomposition product-derived lysophospholipids promote microglial activation in vitro.Scientific reports · 2020Article
- LPIAT, aInternational journal of molecular sciences · 2020Article
- Phospholipid turnover and acyl chain remodeling in the yeast ER.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2020Review
- CDP-Diacylglycerol Synthases (CDS): Gateway to Phosphatidylinositol and Cardiolipin Synthesis.Frontiers in cell and developmental biology · 2020Review
- Multiplexed and single cell tracing of lipid metabolism.Nature methods · 2019Article
- How is the acyl chain composition of phosphoinositides created and does it matter?Biochemical Society transactions · 2019Review
- Sustained phospholipase C stimulation of H9c2 cardiomyoblasts by vasopressin induces an increase in CDP-diacylglycerol synthase 1 (CDS1) through protein kinase C and cFos.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2019Article
- Differential lipid composition and regulation along the hippocampal longitudinal axis.Translational psychiatry · 2019Article
- Phosphatidylinositol Kinases and Phosphatases inFrontiers in cellular and infection microbiology · 2019Review
- Understanding the diversity of membrane lipid composition.Nature reviews. Molecular cell biology · 2018Review
- Features of the Phosphatidylinositol Cycle and its Role in Signal Transduction.The Journal of membrane biology · 2017Review
- Docosahexaenoic acid preserves visual function by maintaining correct disc morphology in retinal photoreceptor cells.The Journal of biological chemistry · 2017Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mammalian phosphatidylinositol (PI) has a unique fatty acid composition in that 1-stearoyl-2-arachidonoyl species is predominant. This fatty acid composition is formed through fatty acid remodeling by sequential deacylation and reacylation. We recently identified three Caenorhabditis elegans acyltransferases (ACL-8, ACL-9, and ACL-10) that incorporate stearic acid into the sn-1 position of PI. Mammalian LYCAT, which is the closest homolog of ACL-8, ACL-9, and ACL-10, was originally identified as a lysocardiolipin acyltransferase by an in vitro assay and was subsequently reported to possess acyltransferase activity toward various anionic lysophospholipids. However, the in vivo role of mammalian LYCAT in phospholipid fatty acid metabolism has not been well elucidated. In this study, we generated LYCAT-deficient mice and demonstrated that LYCAT determined the fatty acid composition of PI in vivo. LYCAT-deficient mice were outwardly healthy and fertile. In the mice, stearoyl-CoA acyltransferase activity toward the sn-1 position of PI was reduced, and the fatty acid composition of PI, but not those of other major phospholipids, was altered. Furthermore, expression of mouse LYCAT rescued the phenotype of C. elegans acl-8 acl-9 acl-10 triple mutants. Our data indicate that LYCAT is a determinant of PI molecular species and its function is conserved in C. elegans and mammals.
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