ArticleDrug and alcohol dependence2012
Childhood adversity, serotonin transporter (5-HTTLPR) genotype, and risk for cigarette smoking and nicotine dependence in alcohol dependent adults.
Article in Drug and alcohol dependence, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Multi-cultural association of the serotonin transporter gene (SLC6A4) with substance use disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2013Pooled it
- Associations Between Childhood Trauma and Tobacco Use Outcomes in Adults after Overnight Abstinence.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2024Article
- Traumatic events during childhood and its risks to substance use in adulthood: an observational and genome-wide by environment interaction study in UK Biobank.Translational psychiatry · 2021Observational
- Drug Addiction: Hyperkatifeia/Negative Reinforcement as a Framework for Medications Development.Pharmacological reviews · 2021Review
- Article
- Youth exposure to violence involving a gun: evidence for adverse childhood experience classification.Journal of behavioral medicine · 2019Article
- New Empirical Evidence on the Validity and the Reliability of the Early Life Stress Questionnaire in a Polish Sample.Frontiers in psychology · 2017Article
- Early life adversity and/or posttraumatic stress disorder severity are associated with poor diet quality, including consumption of trans fatty acids, and fewer hours of resting or sleeping in a US middle-aged population: A cross-sectional and prospective study.Metabolism: clinical and experimental · 2015Article
- Varenicline decreases nicotine but not alcohol self-administration in genetically selected Marchigian Sardinian alcohol-preferring (msP) rats.Drug and alcohol dependence · 2015Article
- The impact of early life stress on risk of tobacco smoking initiation by adolescents.Addictive behaviors · 2015Article
- The relationship between childhood physical and emotional abuse and smoking cessation among U.S. women and men.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2015Article
- Childhood maltreatment and amygdala connectivity in methamphetamine dependence: a pilot study.Brain and behavior · 2014Article
- Interaction between polygenic risk for cigarette use and environmental exposures in the Detroit Neighborhood Health Study.Translational psychiatry · 2013Article
- Adverse Childhood Experiences and the Presence of Cancer Risk Factors in Adulthood: A Scoping Review of the Literature From 2005 to 2015.Journal of pediatric nursingArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundThis study examined the extent to which cigarette smoking and nicotine dependence in adults with alcohol dependence (AD) are associated with adverse childhood experiences. Gender, social support, and an allelic variant in the gene encoding the serotonin transporter (5-HTTLPR) were examined as moderators of this relationship.
methodsThe Semi-Structured Assessment for the Genetics of Alcoholism - Version II (SSAGA-II) was used to assess DSM-IV diagnoses and cigarette smoking characteristics as well as traumatic life events and social support during childhood in 256 AD men (n=149) and women (n=107).
resultsAn increase in number of adverse childhood events was associated with heightened risk of cigarette use and nicotine dependence. 5-HTTLPR genotype, gender, and social support did not significantly moderate the relationships among childhood adversity and ever-smoking or nicotine dependence.
conclusionsResults extend previous findings to suggest that childhood adversity is strongly related to risk for ever-smoking and nicotine dependence in AD individuals. Additional research is needed to examine other potential genetic and environmental moderators and mediators of the relationships among smoking, alcohol use, and childhood trauma.
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