ArticleChemical biology & drug design2012
Virtual design of chemical penetration enhancers for transdermal drug delivery.
Article in Chemical biology & drug design, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Unraveling the Potential of Vitamin BMolecular pharmaceutics · 2024Article
- Current Development of Chemical Penetration Enhancers for Transdermal Insulin Delivery.Biomedicines · 2023Review
- Amorphization of Drugs for Transdermal Delivery-a Recent Update.Pharmaceutics · 2022Review
- Quetiapine Fumarate Extended-release Tablet Formulation Design Using Artificial Neural Networks.Turkish journal of pharmaceutical sciences · 2017Article
- Optical clearing of skin enhanced with hyaluronic acid for increased contrast of optoacoustic imaging.Journal of biomedical optics · 2016Article
- Computational methods in drug discovery.Pharmacological reviews · 2014Review
- Benchmarking ligand-based virtual High-Throughput Screening with the PubChem database.Molecules (Basel, Switzerland) · 2013Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Traditional drug design is a laborious and expensive process that often challenges the pharmaceutical industries. As a result, researchers have turned to computational methods for computer-assisted molecular design. Recently, genetic and evolutionary algorithms have emerged as efficient methods in solving combinatorial problems associated with computer-aided molecular design. Further, combining genetic algorithms with quantitative structure-property relationship analyses has proved effective in drug design. In this work, we have integrated a new genetic algorithm and nonlinear quantitative structure-property relationship models to develop a reliable virtual screening algorithm for the generation of potential chemical penetration enhancers. The genetic algorithms-quantitative structure-property relationship algorithm has been implemented successfully to identify potential chemical penetration enhancers for transdermal drug delivery of insulin. Validation of the newly identified chemical penetration enhancer molecular structures was conducted through carefully designed experiments, which elucidated the cytotoxicity and permeability of the chemical penetration enhancers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.