ArticleCell proliferation2012
Astragalus membranaceus lectin (AML) induces caspase-dependent apoptosis in human leukemia cells.
Article in Cell proliferation, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- A systematic review of anticancer effects of radix astragali.Chinese journal of integrative medicine · 2016Pooled it
- Research advances and prospects of legume lectins.Journal of biosciences · 2021Review
- Phaseolus acutifolius Lectin Fractions Exhibit Apoptotic Effects on Colon Cancer: Preclinical Studies Using Dimethilhydrazine or Azoxi-Methane as Cancer Induction Agents.Molecules (Basel, Switzerland) · 2017Article
- Plant Lectins as Medical Tools against Digestive System Cancers.International journal of molecular sciences · 2017Review
- Structural analysis and unique molecular recognition properties of a Bauhinia forficata lectin that inhibits cancer cell growth.The FEBS journal · 2017Article
- Article
- The Effectiveness of Traditional Chinese Medicine in Treating Patients with Leukemia.Evidence-based complementary and alternative medicine : eCAM · 2016Article
- Cytotoxic and antiproliferative effect of tepary bean lectins on C33-A, MCF-7, SKNSH, and SW480 cell lines.Molecules (Basel, Switzerland) · 2014Article
- Antileukemic activity of Tillandsia recurvata and some of its cycloartanes.Anticancer research · 2014Article
- Abrus agglutinin suppresses human hepatocellular carcinoma in vitro and in vivo by inducing caspase-mediated cell death.Acta pharmacologica Sinica · 2014Article
- Biochemical characterization of a novel L-Asparaginase with low glutaminase activity from Rhizomucor miehei and its application in food safety and leukemia treatment.Applied and environmental microbiology · 2014Article
- Formononetin suppresses the proliferation of human non-small cell lung cancer through induction of cell cycle arrest and apoptosis.International journal of clinical and experimental pathology · 2014Article
- The effects of Gamijinhae-tang on elastase/lipopolysaccharide-induced lung inflammation in an animal model of acute lung injury.BMC complementary and alternative medicine · 2013Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesRecently, plant lectins have attracted great interest due to their various biological activities such as anti-cancer, anti-fungal and anti-viral activities. We have reported earlier concerning anti-proliferation of human cancer cell lines by a galactose-binding lectin (AML), from a Chinese herb, ASTRAGALUS MEMBRANACEUS: In the present study, detailed investigations into the mechanism of such anti-proliferation properties have been carried out. MATERIALS AND
methodsMechanism of apoptosis initiation in K562 cells by AML was investigated by morphology, flow cytometry and western blot analysis.
resultsAML induced apoptosis in a caspase-dependent manner in the chronic myeloid leukemia cell line, K562. Furthermore, we observed that cytotoxicity and apoptosis of K562 cells induced by AML were completely abolished in presence of lactose or galactose.
conclusionsOur results suggest that AML could act as a potential anti-cancer drug.
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