Evidence map›Paper›PMID 22172155›Full record

ArticleJournal of the International Neuropsychological Society : JINS2012

Lifestyle activities and memory: variety may be the spice of life. The women's health and aging study II.

Michelle C Carlson, Jeanine M Parisi, Jin Xia, Qian-Li Xue, George W Rebok, Karen Bandeen-Roche, Linda P Fried

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Journal of the International Neuropsychological Society : JINS, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07730671 (Evaluation of the Long-Term Cognitive, Biological, and Lifestyle Effects of a Multimodal Intervention for Preventing Cognitive Decline in APOE-ε4 Carriers With Subjective Cognitive Decline), which is not on this map. Cited by 78 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed, 1 pooled it
16.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07730671 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Evaluation of the Long-Term Cognitive, Biological, and Lifestyle Effects of a Multimodal Intervention for Preventing Cognitive Decline in APOE-ε4 Carriers With Subjective Cognitive Decline

TypeobservationalSponsorBarcelonabeta Brain Research Center, Pasqual Maragall FoundationRan2026 to 2028Enrolled121ConditionsSubjective Cognitive Decline (SCD)
3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 1 synthesis or guideline pooled it, 160 citations in OpenAlex.

  1. Pooled it
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  4. Variety of Enriching Early-Life Activities Linked to Late-Life Cognitive Functioning in Urban Community-Dwelling African Americans.The journals of gerontology. Series B, Psychological sciences and social sciences · 2019
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  15. Longitudinal associations of life space mobility and domain-specific cognitive measures in ACTIVE.Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition · 2025
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18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Michelle C CarlsonDepartment of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Jeanine M Parisi
Jin Xia
Qian-Li Xue
George W Rebok
Karen Bandeen-Roche
Linda P Fried
Johns Hopkins University · USColumbia University · US

Funding

'T V ASSESSMENT - MEMORY DISORDERED PATIENTS'P50AG005146 · NIA · JOHNS HOPKINS UNIVERSITY · PI TRONCOSO, JUAN · 1985 to 2019
$37.6M
Research Infrastructure for the Hopkins Population CenterR24HD042854 · NICHD · JOHNS HOPKINS UNIVERSITY · PI CHERLIN, ANDREW J · 2003 to 2017
$5.1M
RISK FACTORS FOR PHYSICAL DISABILITY IN AGING WOMENR01AG011703 · NIA · JOHNS HOPKINS UNIVERSITY · PI FRIED, LINDA P · 1994 to 2004
$3.5M
PREVENTIVE RESEARCH TRAINING IN MENTAL HEALTHT32MH018834 · NIMH · JOHNS HOPKINS UNIVERSITY · PI IALONGO, NICHOLAS S · 1988 to 2011
$2.3M
Cognitive Pathways to DisabilityR01AG019825 · NIA · JOHNS HOPKINS UNIVERSITY · PI CARLSON, MICHELLE C · 2002 to 2006
$2.1M
NIA NIH HHS P50 AG005146NIA NIH HHS R01 AG011703NIA NIH HHS R01 AG019825NIA NIH HHS R01 AG11703-01A1NICHD NIH HHS R24 HD042854NIMH NIH HHS T-32 MH018834NIMH NIH HHS T32 MH018834
6 · The paper itself

Abstract

This study examined whether participation in a variety of lifestyle activities was comparable to frequent participation in cognitively challenging activities in mitigating impairments in cognitive abilities susceptible to aging in healthy, community-dwelling older women. Frequencies of participation in various lifestyle activities on the Lifestyle Activities Questionnaire (LAQ) were divided according to high (e.g., reading), moderate (e.g., discussing politics), and low (e.g., watching television) cognitive demand. We also considered the utility of participation in a variety of lifestyle activities regardless of cognitive challenge. Immediate and delayed verbal recall, psychomotor speed, and executive function were each measured at baseline and at five successive exams, spanning a 9.5-year interval. Greater variety of participation in activities, regardless of cognitive challenge, was associated with an 8 to 11% reduction in the risk of impairment in verbal memory and global cognitive outcomes. Participation in a variety of lifestyle activities was more predictive than frequency or level of cognitive challenge for significant reductions in risk of incident impairment on measures sensitive to cognitive aging and risk for dementia. Our findings offer new perspectives in promoting a diverse repertoire of activities to mitigate age-related cognitive declines.

Indexed as

Activities of Daily LivingLife StyleAgedAged, 80 and overAgingCohort StudiesFemaleHumansMental Status ScheduleNeuropsychological TestsProportional Hazards ModelsSurveys and Questionnaires

Identifiers

PMID22172155
PMCPMC3508669
OpenAlexW2127782874

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.